Medicinal Chemistry: Anaesthesia and Analgesia lecture Flashcards
1
Q
How is Cocaine isolated
A
Cocaine is isolated from natural sources
2
Q
Procaine
A
Local anaesthetic
3
Q
Which Local Anaesthetics has longer duration of action
A
Lidocaine (Amino amide)
4
Q
Henderson-Hasselbalch Equation
A
what % of drug is ionised in a particular point of the body
5
Q
pH of skin
A
5.5
6
Q
pH of blood plasma
A
7.4
7
Q
local anaesthetics are
A
weak bases
8
Q
How do local anaesthetics work
A
- local anaesthetics work by blocking sodium channels
- for a local anaesthetic to work some must be de-protonated
9
Q
Tetracaine has
A
2 ionisable centres
10
Q
Local Anaesthetics: SAR
A
Need to have an aromatic group, lipophilic group and at least one ionisable group
11
Q
Zwitterionic
A
ion which has a positive and negative charge
12
Q
Codeine activity
A
codeine has no activity as an opioid
13
Q
Opioid Analgesics
A
weak bases
14
Q
4-Phenylpiperidines
A
- used widely as analgesia in child birth for anaesthetic of lower back
- lower activity than morphine and shorter duration of action
