Medications ADRs

Question 1

Rifampicin

Answer 1

Drug interactions, hepatitis, hypersensitivity, orange urine

Question 2

Isoniazid

Answer 2

Hepatitis, rash, peripheral neuropathy

Question 3

Ethambutol

Answer 3

Optic neuropathy

Question 4

Pyrazinamide

Answer 4

Hepatitis, skin, polyarthralgia, gout

Question 5

Hepatitis commonly due to what TB medication

Answer 5

Pyrazinamide > Isoniazid&raquo_space; Rifampicin. ALT 2-5xULN + ASx - monitor. >5x ULN or >3xULN + Sx - stop. Once ALT baseline - re-challenge

Question 6

Drug resistance TB (MDR-TB)

Answer 6

Isoniazid most common + rifampicin

Question 7

vincristine

Answer 7

peripheral neuropathy, vesicant extravasation

Question 8

vesicant cytotoxic drugs

Answer 8

Cisplatin (if > 0.4 mg/mL)
Daunorubicin
Docetaxel
Doxorubicin
Epirubicin
Idarubicin
Mechlorethamine
Mitomycin C
Mitoxantrone
Oxaliplatin
Paclitaxel
Vinblastine
Vincristine
Vinorelbine

Question 9

Lapatinib ADR

Answer 9

Palmar-plantar erythrodysthesia. EGFR and HER2 receptor antagonist

Question 10

Cyclophosphamide ADR

Answer 10

Haemorrhagic cystitis, pericardial effusion/pericarditis

Question 11

Docetaxel

Answer 11

sensory/motor polyneuropathy, neutropenic sepsis, hypersensitivity

Question 12

Cabazitaxel

Answer 12

diarrhoea, cytopaenia, sensoimotor PN (less common than DCX), less alopecia

Question 13

Abiraterone

Answer 13

HTN, hypokalaemia, peripheral oedema, transaminitis