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FRACP > mAbs > Flashcards

mAbs Flashcards

1
Q

Bezlotoxumab

A

C.Difficile toxin B (used in multiple recurred disease >2)

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2
Q

Vedolizumab

A
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3
Q

Eculizumab

A
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4
Q

Bevacizumab

A
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5
Q

Trastuzumab

A

HER2 receptor aka Herceptin

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6
Q

Tocilizumab

A

anti-IL-6

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7
Q

Baricitinib

A

JAK-1/2 inhibitor

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8
Q

Remdesivir

A

inhibits RNA-dependent RNA polymerase

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9
Q

Ipilimumab

A

cytotoxic T lymphocyte associated antigen 4 (CTLA-4)

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10
Q

Osimertinib

A

EGFR TKI in palliative EGFR mut NSCLC and EGFR T790M mutation (Rash most common SE)

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11
Q

Ramucirumab

A

anti-VEGFR2 (anti-angiogenesis) in 2nd line gastric Ca (palliative intent)

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12
Q

Zolbetuximab

A

Claudin 18.2 (tight junction protein in gastric mucosa) –> cell death by ADCC, complement mediation

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13
Q

Olaparib

A

PARP inhibition (BRCA mut) - inhibits poly(ADP‐ribose) polymerase, thereby blocking the repair of single‐strand DNA breaks

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14
Q

Durvalumab

A

anti-PD1

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15
Q

Tamoxifen

A

Selective (o)sterogen receptor modulator (SERM). Risk VTE, endometrial Ca

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16
Q

Aromatase inhibitor

A

Reduces oestrogen biosynthesis. Risk: osteoporosis

17
Q

Abemaciclib, Palbociclib, Ribociclib

A

CD4/6 inhibitor (CKD-Rb1-E2F essential for progression through cell cycle (blocks phosphorylation of Rb))

18
Q

Alpelisib

A

alpha-specific PI3K inhibitor (endocrine resistant HR+/HER2- advanced breast ca)

19
Q

Trastuzumab deruxtecan

A

anti_HER2 IgG1 mAb + Topo I inh payload. ADR - N&V, diarrhoea, alopecia, ILD

20
Q

Sacituzumab govitecan

A

anti-TROP2 mAb + Topo I inh. Toxicity: myelosuppression, diarrhoea, alopecia.

21
Q

aprepitant

A

Neurokinin-1 (NK-1) receptor antagonist - used in chemotherapy-induced N&V. Substance P (emesis provoking) binds NK-1R (area postrema and the nucleus tractus solitarius)

22
Q

ondansetron

A

5-HT3 antagonist

23
Q

Olaparib

A

PARP inhibitor. N&V, anaemia.

24
Q

Docetaxel / Cabazitaxel

A

Stabilises microtubules during mitosis/interphase → mitotic arrest and cell death

25
Q

Abiraterone

A

Inhibits 17alpha-hydroxylase and c17, 20-lyase (androgen biosynthesis inhibitor)

26
Q

Enzalutamide and Apalutamide, Darolutamide

A

Androgen receptor inhibitor. Darolutamide - less BBB penetration (less CNS toxicity)

27
Q

Avelumab

A

PD-L1i in maintenance Tx for metastatic urothelial Ca/TCC

28
Q

Enfortumab Vedotin

A

Nectin-4 Ab conjugate - 3rd line Tx in mTCC. ADRs; Rash, hyperglycaemia, peripheral neuropathy

29
Q

Belimumab

A

B-lymphocyte stimulator (BLyS)-specific inhibitor in SLE for lupus nephritis (add-on therapy)

30
Q

Anifrolumab

A

Anti-type I IFN receptor in SLE

31
Q
A
32
Q
A
33
Q
A

FRACP (6 decks)

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