medications Flashcards
Adrenaline
Presentation
1mg: 1ml
1mg: 10ml
Adrenaline
Pharmacology
Naturally occurring alpha & beta adrengic stimulant
Increasing HR increasing firing through SA node (beta 1)
Increasing conduction velocity through the AV node (beta 1)
Increased Myocardial contractility (beta 1)
Increased Ventricular irritability (beta 1)
Vasoconstriction (alpha)
bronchodilation (beta 2)
Adrenaline
Primary emergency indication
Cardiac arrest (PEA, asystole, Pulseless VT or VF)
Inadequate perfusion (cardiogenic/non-cardiogenic)
Bradycardia with poor perfusion
Anaphylaxis
Croup - severe
Asthma- Unconscious with no BP, imminent life threat, not responding to nebulised treatment
Adrenaline
Contraindications
Hypovolaemic shock without adequate fluid replacement
Adrenaline
Precautions
Consider reduced doses for
- Pts with cardiovascular disease
- Pts on monoamine oxidase inhibitors
- Elderly/frail pts
Consider higher doses for
- Pts on beta blockers
Adrenaline
Side effects
Sinus tachycardia Hypertension Ventricular arrhythmias Feeling of anxiety/palpations May increase size of Myocardial infarctions Pupil dilation Supraventricular arrhythmias
Adrenaline
Times
IV
Onset 30seconds
Peak 3-5minutes
duration 5-10minutes
IM
Onset 30-90seconds
Peak 4-10minutes
duration 5-10minutes
Adrenaline
Metabolism
Metabolised by - monoamine oxidase and other enzymes in blood - liver - nerve endings excreted by kidneys
Aspirin
Presentation
300mg
Aspirin
Pharmacology
an analgesic, antiplatelet, anti-inflammatory, anti-pyretic
Works to minimise platelet aggregation & thrombus formation to retard the progression of coronary artery thrombus in ACS
Inhibit prostaglandin synthesis - anti-inflammatory actions
Aspirin
Metabolism
convert to salicylate in gut mucosa & liver
excreted by kidneys
Aspirin
Primary emergency indications
Acute coronary syndrome (ACS)
Aspirin
Contraindications
Hypersensitivity Actively bleeding peptic ulcer Bleeding disorders Chest pain associated with psychostimulant overdose with SBP >160mmHg Suspected dissecting aortic aneurysm
Aspirin
Precautions
Peptic ulcer
Asthma
Pts on other anti-coagulates
Aspirin
Side effects
Heartburn, nausea, gastrointestinal bleeding
Increased bleeding time
Hypersensitivity
Aspirin
Times
Onset n/a
Peak n/a
Duration 8-10days
Ceftriaxone
Presentation
1 g sterile powder in a glass vial
Ceftriaxone
Pharmacology
cephalosporin antibiotic
Ceftriaxone
Metabolism
excreted in urine & bile
Ceftriaxone
Primary emergency indications
Meningococcal septicaemia Severe sepsis (consult only)
Ceftriaxone
Contraindications
Allergy to cephalosporin antibiotics
Ceftriaxone
Precautions
Allergy to Penicillin antibiotics
Ceftriaxone
Side effects
Nausea
Vomiting
Skin rash