Medications

Question 1

What affects does trimethoprim have on the kidney

Answer 1

Pseudo AKI

inhibits proximal renal tubular creatinine secretion leading to increase in serum creatinine (no affect on GFR)

Question 2

What part of the kidney do thiazides act? What do they do? What are the side effects?

Answer 2

Distal tubule

Inhibits Na secretion therefore increasing Ca re-absorbtion

Hypokalemia and diabetes (insulin secretion impairment)

Question 3

What affect does aminoglycosides have on kidney?

Answer 3

Proximal tubule injury and vasoconstriction

Can impact re-absorption

Advised to given in single daily dosing vs. TID (saturation phenomenon)

Question 4

How does cisplatin work and what are side effects?

Answer 4

1. Inhibits DNA replication through intra-strand cross links

2. Nephrotoxicity, immunosuppression, thrombocytopenia, ototoxicity

Question 5

How doe Paclitaxel work and what are side effects?

Answer 5

1. Intereferes with assembly of microtubules

2. Myelosuppression, peripheral neuropathy

Question 6

How doe Gemcitabine work and what are side effects?

Answer 6

1. Inhibits DNA synthesis

2. Myelosuppression, nausea/vomiting, transaminitis

Question 7

Atezolizumab, Durvalumab, and Avelumab are all examples of what type of drug

Answer 7

PDL-1 inhibitors

Question 8

Pembrolizumab and Nivolumab are all examples of what type of drug?

Answer 8

PD-1 inhibitors

Question 9

What are some common side effects of check point inhibitors?

Answer 9

colitis, endocrinopathies, nephritis, liver toxicity, skin rash or pruritis, and pneumonitis

Question 10

What are some side effects of carboplatin?

Answer 10

Myelosuppression and electrolyte abnormalities

Question 11

What are some side effects of methotrexate?

Answer 11

Cardiovascular, CNS, transaminitis, myelosuppression

Question 12

What are some side effects of Vinblastine?

Answer 12

HTN, Ostealgia, jaw necrosis myelosuppresion

Question 13

What are some side effects of adriamycin?

Answer 13

Cardiac, myelosuppression

Question 14

When is Finasteride indicated?

Answer 14

LUTS + Enlarged prostate (> 40g)

Question 15

When is it safe to resume flomax after cataract surgery ?

Answer 15

2 weeks

Question 16

how does vitamin C cause stones?

Answer 16

hyperuxaluria

Question 17

Which PDE5i is less likely to results in blurred vision?

Answer 17

Tadalafil

Question 18

Which PDE5i has the shortest onset?

Answer 18

avanafil

Question 19

What are the contraindications to cisplatin?

Answer 19

Renal insufficiency (GFR < 60)
Peripheral neuropathy
Hearing loss
poor performance status
heart failure (New York Heart Association class 3 or

Question 20

Which drugs increase bleeding risk of Warfarin?

Answer 20

Aminoglycosides
Allopurinol
Aminosalicylic Acid
Chloramphenicol
Cimetidine
Ethacrynic Acid
Fluoroquinolone
Indomethacin
Isoniazid
Metronidazole
Miconazole
Nalidixic Acid
Oxyphenbutazone
Sulfonadmides
teteracycline
Trimethroprim

Question 21

What medications are metabolized through Cytochrome P450 (liver0?

Answer 21

PDE5i

Warfarin

Question 22

What are some inhibitors of the Cytochrome P450 pathway?

Answer 22

Azole antifungals
Protease inhibitors
macrolides

Question 23

MOA of anticholinergic and contraindications

Answer 23

Prevent binding of acetylcholine to prevent muscle contraction

Contraindications: narrow angle glaucoma