Medications Flashcards
Diazepam (Valium) classification
Benzodiazepine
Diazepam (Valium) action:
Binds to the benzodiazepine receptor and enhances the effects of GABA. Benzodiazepines act at the level of the limbic, thalamic, and hypothalamic regions of the CNS and can produce any level of CNS depression required (including sedation, skeletal muscle relaxation, and anticonvulsant activity).
Diazepam (Valium) indications
Anxiety, skeletal muscle relaxation, alcohol withdrawal, seizures
Diazepam (Valium) adverse effects:
Respiratory repression, drowsiness, fatigue, headaches, pain at injection site, confusion, nausea, hypotension, oversedation
Diazepam (Valium) contraindications:
Children younger than 6 months
acute angle glaucoma
CNS depression
Alcohol intoxication
Allergy
Diazepam (Valium) dosage - adult anxiety
Moderate: 2-5 mg slow IV/IM
Severe: 5-10 mg slow IV/IM (no faster than 5 mg/min)
Low: Low dosages are often required for elderly or debilitated patients
Diazepam (Valium) dose for acute alcohol withdrawal - adult
10 mg IV
Diazepam (Valium) adult seizure dose:
5-10 mg slow IV/IO every 10-15 minutes
MAX dose of 30 mg
Lorazepam trade name
Ativan
Lorazepam (Ativan) classification
Benzodiazepine
Lorazepam (Ativan) action
Binds to benzodiazepine receptor and enhances the effects of the brain chemical GABA, an inhibitory transmitter, and may result in hypnosis, skeletal muscle relaxation, anticonvulsant activity, coma
Lorazepam (Ativan) indications
Preprocedural sedation induction, anxiety, status epilepticus
Lorazepam (Ativan) adverse effects
Headache, drowsiness, ataxia (loss of muscle coordination), dizziness, amnesia, depression, dysarthria (Weakness in the muscles used for speech, which often causes slowed or slurred speech), euphoria, syncope, fatigue, tremor, vertigo,
Lorazepam (Ativan) contraindications
Allergy to benzodiazepines, lorazepam, polyethylene glycol, propylene glycol, or benzyl alcohol
COPD
Sleep apnea
Shock
Coma
Acute-angle glaucoma
Lorazepam (Ativan) adult seizure dosage
Adult: 2-4 mg IV/IO given over 2-5 minutes
May repeat in 10-15 minutes
MAX dose 8 mg in a 12 hour period
Pregnancy class D
What is phenytoin (Dilantin) for?
Anticonvulsant
What is carba,azepine (Tegretol) for?
Anticonculsenat
Can also be prescribed for many other conditions
What is Levetiracetam (Kepptra) for?
Anticonvulsant
What is Gabapentin (Neurontin) for?
Anticonvulsant
Lamotragine (Lamictal)
Anticonvulsant, antimanic agent
What is an osmotic diuretic
Osmotic diuretics pull fluid out of tissues and cells and move it into the vascular space, where excessive fluids can be filtered out in urine. In ICP it reduces water in the brain and decreases pressure.
Mannitol trade name
Osmitrol
Mannitol (Osmitrol) classification
Osmotic diuretic
Mannitol (Osmitrol) Action
facilitates the flow of fluid out of tissues (including the brain) and into interstitial fluid and blood, thereby dehydrating the brain and reducing swelling. Reabsorption by the kidney is minimal c consequently increasing urine output.
Mannitol (Osmitrol) indications
ICP
Mannitol (Osmitrol) adverse effects
Pulmonary edema, headache, blurred vision, dizziness, seizures, hypovolemia, nausea/vomiting, diarrhea, electrolyte imbalances, hypotension, hypertension, sinus tachycardia, premature ventricular contractions, angina, phlebitis (inflammation of a vein)
Mannitol (Osmitrol) contraindications
Active intracranial bleeding
heart failure
pulmonary edema
severe dehydration
Use with caution in hypovolemia and renal failure
Mannitol (Osmitrol) adult dose
0.25-1 g/kg IV/IO followed by 0.25-1 g/kg infused over 20-30 minutes administered every 4 hours
Hypertonic saline (3% saline) classification
volume expander
electrolyte solution
Hypertonic saline (3% saline) action
The hypertonic nature of this fluid pulls extravascular fluid into the vascular space. Hypertonic saline may therefore be used as a volume expander in cases of hypovolemia or to reduce edema of the swollen brain.
Hypertonic saline (3% saline) indications
Reduction of increased ICP resulting from TBI, hypovolemic shock
Hypertonic saline (3% saline) contraindications
Pulmonary congestion
pulmonary edema
known hypersensitivity
Should NOT be administered by the IO route
Hypertonic saline (3% saline) dosage adult
300 mL bag IV over 20 minutes
Phenytoin trade name
Dilantin
Phenytoin (Dilantin) classification
Anticonvulsant
Phenytoin (Dilantin) action
Depresses seizures by affecting the movement of sodium and calcium into neural tissues
Phenytoin (Dilantin) indications
Generalized tonic clonic seizures
Phenytoin (Dilantin) adverse effects
Nausea
Vomiting
depression of cardiac conduction
sedation
nystagmus
tremors
ataxia
dysarthria
gingival hypertrophy (gum enlargement)
hirsutism (male like hair growth in women)
facial coarsening
hypotension
Phenytoin (Dilantin) contraindications
Sinus bradycardia
Sinoatrial block
Second and third degree heart block
Adams-stokes syndrome
known sensitivity
Phenytoin (Dilantin) adult dosage
15-20 mg/kg IV slowly
Do not exceed 50 mg/min
Phenytoin (Dilantin) special considerations
Continuously monitor the ECG and BP
Monitor IV site for infiltration
Pregnancy class D
Midazolam trade name
Versed
Midazolam (Versed) classification
Benzodiazepine
Midazolam (Versed) action
Binds to the benzodiazepine receptor and enhances the effects of the brain chemical (neurotransmitter) GABA. Benzodiazepines act at the level of the limbic, thalamic, and hypothalamic regions of the CNS to produce short-acting CNS depression (including sedation, skeletal muscle relaxation, and anticonvulsant activity).