MEDICATION TRIALS Flashcards
What is OMECAMTIV MECARBIL?
A myosin ATPase activator that enhances myosin crossbridge and reduces heart failure.
Known as omecamtiv-ator.
What was the focus of the PIONEER TRIAL?
To evaluate the effects of OMECAMTIV MECARBIL in heart failure.
This trial specifically assessed the drug’s efficacy.
What is MAVACAMTEN?
A myosin inhibitor targeting excessive contractility and impaired relaxation.
It aims to improve NYHA and exercise capacity.
What does MAVACAMTEN improve?
NYHA classification and exercise capacity.
NYHA stands for New York Heart Association classification.
What was the focus of the GALACTIC HF trial?
To evaluate MAVACAMTEN in patients with heart failure.
This trial specifically assessed the drug’s efficacy.
What is VERICIGUAT?
A guanylate cyclase stimulator that induces nitric oxide (NO).
It is used in the treatment of heart failure.
What was the focus of the VICTORIA TRIAL?
To evaluate the effects of VERICIGUAT in heart failure patients.
This trial highlighted the drug’s impact on heart failure management.
