CRT TRIALS

Question 1

Which trial first demonstrated that CRT was better than no CRT in NYHA III-IV patients?

Answer 1

MUSTIC

Question 2

What was the first randomized controlled trial (RCT) that led to FDA approval of CRT?

Answer 2

MIRACLE

Question 3

Improved NYHA class, quality of life (QoL), and 6-minute walk test (6MWT)

Answer 3

MIRACLE

Question 4

How did MIRACLE ICD differ from MIRACLE?

Answer 4

Included CRT-D but showed no significant difference in 6MWT

Question 5

Which trial was the first to include NYHA II patients?

Answer 5

CONTAK CD

Question 6

Optimal medical therapy (OMT) vs. CRT-P (pacing) vs. CRT-D (defibrillator)

Answer 6

COMPANION

Question 7

What was the first trial to include mortality as an endpoint?

Answer 7

COMPANION

Question 8

CRT + OMT was better than OMT alone

Answer 8

CARE HF

Question 9

Which trial demonstrated the benefit of CRT on LV reverse remodeling?

Answer 9

REVERSE

Question 10

Which trial showed a benefit of CRT-D vs ICD alone in LBBB patients for primary prevention?

Answer 10

MADIT-CRT

Question 11

What was the first trial to show that CRT-D was superior to ICD alone?

Answer 11

RAFT

Question 12

What was the significance of REVERSE, MADIT-CRT, and RAFT in CRT use?

Answer 12

These trials led to FDA expansion of CRT for mildly symptomatic HF (NYHA I-II)

Question 13

Which trial showed that CRT was contraindicated in patients with a narrow QRS?

Answer 13

ECHO-CRT

Question 14

CRT vs. RV pacing in patients requiring pacing with LVEF <50%

Answer 14

BLOCK HF

Question 15

CRT was superior to RV pacing, supporting CRT use in patients with LVEF <50% needing pacing

Answer 15

BLOCK HF