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Medication Profiles Flashcards

1
Q

What class of drug is carboplatin?

A

Alkylating agents

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2
Q

What is the contraindication for carboplatin?

A

Known hypersensitivity

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3
Q

What class is cyclophosphamide?

A

AA

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4
Q

What is the formula for GFR?

A

N = 1.04 (females) and 1.23 (males)

GFR = N x (140-Age) x Weight (in kg)
___________________________
Serum creatinine

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5
Q

What class is cisplatin?

A
  • AA

- Platinum compound type

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6
Q

What is a contradiction for cisplatin?

A
  • Severe renal impairment (nephrotoxic)
  • Myelosuppresion
  • Hearing impaired (ototoxic)
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7
Q

What class is doxorubicin?

A

Anthracycline antibiotic

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8
Q

What is the contraindication for doxorubicin?

A
  • Hypersensitivity
  • Lifetime max dose **
  • Severe hepatic impairment
  • Cardiac issues (cardiotoxic)
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9
Q

What class does rituximab belong to?

A

Monoclonal antibodies

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10
Q

What is the contraindication for rituximab?

A

Previous hypersensitivity

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11
Q

What are the precautions for rituximab?

A
  • 1st time reactions ** decreased with subsequent infusions
  • TLS (with increased tumor burden)
  • age >65, greater risk of cardiac/pulm toxicities
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12
Q

What drug class is paclitaxel?

A

Plant alkaloid, antimicrotuble agent

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13
Q

What is the contraindication for paclitaxel?

A
  • Pre-existing liver impairment
  • Elderly
  • AIDS
  • Caution: no live vaccines
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14
Q

What class does vincristine belong to?

A

Vinka alkaloids

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15
Q

What is the contraindication for vincristine?

A
  • Neuropathies

- Liver failure

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16
Q

What class does oxaliplatin belong to?

A

AA

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17
Q

What are contraindications for oxaliplatin?

A
  • hypersensitivities to platinums (carbo, cis)
  • peripheral neuropathies
  • CKD (<30 GFR)
  • Cardiac hx (prolonged QT) (use with caution)
18
Q

What class does fluorouracil belong to?

A

Antimetabolites

19
Q

What are the contraindications for fluorouracil?

A

Hypersensitive reactions to it or capectibine

20
Q

What class does etoposide belong to?

A
  • Vinca alkaloids, topo inhibitor

- cycle specific to S and G2 phase

21
Q

What class does irinotecan belong to?

A
  • Plant alkaloids, topo inhibitors

- S phase specific

22
Q

What are the main adverse effects of aklylating agents as a group?

A 
Myelosuppresion
Sterility
N/V
Diarrhea
Neuropathies - peripheral and central (oto and oculuar)
Alopecia
TLS and SIADH
Renal toxicity - electrolyte disturbance
23
Q

What are the main adverse effects of anti-tumor ABX as a group?

A

Myelosuppresion
Cardiotoxic
TLS

24
Q

What group of drugs causes renal toxicity?

25
Q

What groups of drugs cause liver toxicity?

A

AA’s and vinca alkaloids

26
Q

What group of drugs causes neurotoxicities?

A

AA’s

Includes peripheral and central (eyes, ears)

27
Q

What drugs cause cardiac toxicity?

A 
Paclitaxel
Rituximab
Oxaliplatin
Doxorubicin
Fluorouracil

Fussy ducks observed raccoons playing

28
Q

What is the main adverse effects of anti-metabolites?

A

Myelosuppression
Skin/derm changes - PPE and mucositis
Diarrhea

29
Q

What is the main adverse effects of MAb’s?

A 
Hypersensitive reactions
TLS (12-24 hours post)
Myelosuppresion
Nausea
Fever/chills
Rash
30
Q

What is the main adverse effects of vinca alkaloids?

A 
Myelosuppresion
N/v
Mucositis
Muscle aches / cholinergic responses
ECG changes
Neuropathies
TLS and SIADH
Alopecia
Constipation (sometimes diarrhea, irinotecan and etoposide)
31
Q

What is the key side effect of doxorubicin?

A 
Red pee 1-2 days
GI symptoms (n/v and diarrhea, sore mouth) (think of how ABX trash the GI usually)
Pigmentation changes
32
Q

What is the key side effect of cyclophosphamide?

A

Cystitis

Drink ++ water and pee frequently

33
Q

What is the key side effect of cisplatin?

A 
Multiple toxicities (renal, neurological)
(Encourage to drink + water for renal)
34
Q

What is the key side effect of paclitaxel?

A

Hypersensitivity reactions

Fever and myalgia’s first 24 hours

35
Q

What is the key side effect of oxaliplatin?

A

Cold dysthesias

36
Q

What is the key side effect of rituximab?

A

Hypersensitive reactions **

Fever and chills 24x hours after tx

37
Q

What is the key side effect of fluororacil?

A

PPE, cardiotoxic

Have seen ASAP if any heart changes

38
Q

What is the key side effect of etoposide?

A

++ GI issues (diarrhea or const)
Sore mouth
Alopecia

39
Q

What is the key side effect of irinotecan?

A

Diarrhea

No radiation at the same time!

40
Q

What is a key side effect of carboplatin?

A

Ocular and ototoxicity

Assess for signs

41
Q

What drugs from the guide manual cause alopecia?

A

Doxorubicin
Paclitaxel
Etoposide

Chemo Training (11 decks)

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