Medication

Question 1

What drug has an action on the ascending limb of the loop of henle?

Answer 1

Frusemide - diuretic
Inhibits sodium potassium chloride channel
25% filtered sodium excreted.

Question 2

What’s the function of Thiazides?

Answer 2

Diuretic acting on the distal tubule and connecting segment.
Sodium chloride carrier inhibition.
3-5% of filtered sodium excreted.

Question 3

What diuretic causes a 1-2% of filtered sodium excreted.

Answer 3

Spironolactone.

Question 4

What’s the effect of NSAIDS on the kidney?

Answer 4

NSAIDs inhibit COX-1 and COX-2 which inhibit the production of prostaglandins.
Prostaglandins cause vasodilation in the afferent arterioles which increases GFR.
As NSAIDS inhibit this they decrease GFR.