medical problems Flashcards
- A black multigravid woman who underwent a CS for failure to progress after an induction for PET complicated by endometritis, comes to see you 5/52 post partum with fatigue/dyspnoea/orthopnoea. O/E HR 110, BP 140/95, pretibial oedema, RUQ tenderness, fine crackles at both bases, CXR cardiomegaly, temp 36.7. What is Dx?
a) Post partum cardiomyopathy
b) Mitral stenosis
c) Pulmonary hypertension
d) Bacterial endocarditis
a) Post partum cardiomyopathy
- Red degeneration of a fibroid:
a) Causes an elevation of the ESR
b) Causes leucopaenia
c) Only occurs in pregnancy
d) Occurs due to embolisation of the feeding vessels
a) Causes an elevation of the ESR
- A woman is pregnant after bromocriptine treatment of a pituitary macroademoma. Management during pregnancy should include:
a) Continue bromocriptine
b) Visual field assessment
c) Xray sella turcica
d) Neurosurgery
b) Visual field assessment
- A multiparous woman presents 8 weeks post partum complaining of tiredness, palpitations and tremor. She has been losing weight and is unable to sleep. Pulse is 100 bpm, BP 160/90. The most likely diagnosis is:
a) HIV
b) Anxiety
c) Drug abuse
d) Thyrotoxicosis
d) Thyrotoxicosis
- Which is the most incorrect statement regarding the management of ITP?
a) LUSCS is of no benefit to fetus with known severe thrombocytopaenia
b) Fetal risk increases if the mother has a past history of splenectomy
c) Fetal scalp sampling shouldn’t be used because of the risk of bleeding
d) Maternal steroids should be given if the platelet count drops below 100
e) Fetal risk can be determined by maternal antibody titre
e) Fetal risk can be determined by maternal antibody titre
- What woman has the best reproductive future?
a) PG Eclamptic fit with DIC, BP normal at 6/52
b) Multi with severe preeclampsia, BP normal at 3 months
c) Preeclampsia with diastolic BP 100mmHg at 3 months
d) Woman with essential hypertension
e) Woman with chronic renal failure, currently stable
d) Woman with essential hypertension
1st ANC visit, 22yo primip, mother is NIDDM. No glycosuria. You advise the patient:
a) No chance that she will get diabetes
b) Need GTT in 2nd trimester
c) Start prophylactic insulin
d) If doesn’t get glycosuria in pregnancy, no risk of diabetes
e) Monitor her by doing fasting BSL in pregnancy
b) Need GTT in 2nd trimester
What percentage of patients are negative for HpA1a antigen?
a) 0.0002%
b) 0.02%
c) 0.2%
d) 2%
e) 20%
d) 2%
- Which of the following is most normal in a normal pregnancy?
a) MCV 105
b) WCC 12
c) Platelets 100,000
d) Reticulocytes 15%
b) WCC 12
Regarding Bell’s Palsy:
a) It is caused by compression of the facial nerve in the pterygopallatine fossa
b) It responds to NSAID’s
c) It causes a sensory nerve deficit
d) It is most common in late pregnancy
d) It is most common in late pregnancy
Acute peripheral facial nerve palsy of unknown cause
Paralysis of the facial nerve, typically involving all three peripheral branches, resulting in asymmetric facial expression and unilateral weakness of eye closure. There is a two- to fourfold increase in prevalence during pregnancy, especially in the third trimester or in the first postpartum week
Perineural edema, hypercoagulability causing thrombosis of the vasa nervosum, and relative immunosuppression in pregnancy have been proposed as potential etiologic factors appears to be an association with preeclampsia
The mainstay of pharmacologic therapy for Bell’s palsy is early short-term oral glucocorticoid treatment
no additional benefit for antiviral therapy
- Mother has anti Ro detected. What is the risk of congenital complete heart block in the fetus?
a) <5%
b) 10%
c) 20%
d) 30%
e) 40%
a) <5%
- The CLASP trial demonstrated that aspirin 60mg daily could:
a) Reduce severe early onset IUGR associated with PET
b) Reduce IUGR
c) Both
d) Neither
d) Neither
CLASP: Reduce the likelihood of PTD in women at risk of early onset severe PET.
In our multicentre study 9364 women were randomly assigned 60 mg aspirin daily or matching placebo. 74% were entered for prophylaxis of pre-eclampsia, 12% for prophylaxis of IUGR, 12% for treatment of pre-eclampsia, and 3% for treatment of IUGR. Overall, the use of aspirin was associated with a reduction of only 12% in the incidence of proteinuric pre-eclampsia, which was not significant. Nor was there any significant effect on the incidence of IUGR or of stillbirth and neonatal death. Aspirin did, however, significantly reduce the likelihood of preterm delivery (19.7% aspirin vs 22.2% control; absolute reduction of 2.5 [SD 0.9] per 100 women treated; 2p = 0.003). There was a significant trend (p = 0.004) towards progressively greater reductions in proteinuric pre-eclampsia the more preterm the delivery. Aspirin was not associated with a significant increase in placental haemorrhages or in bleeding
- Your 16/40 patient has a Mantoux reaction of 16mm. She is asymptomatic and CXR is normal. What is the best management?
a) Vaccinate with BCG
b) Reassure and review postnatally
c) Isoniazid 300mg daily for 6 months
d) Isoniazid 300mg daily for 12 months
e) Rifampicin 100 mg daily for 12 months
b) Reassure and review postnatally
If a skin test has been performed in the absence of an indication for prompt LTBI management and is positive, a chest radiograph should be performed. Delaying therapy is appropriate for patients with positive TST in the absence of a major risk factor for progression to active disease, ie, recent infection or immunosuppression. Therapy may be initiated three months after delivery to minimize concern for hepatitis in the postpartum period. If treatment for LTBI is deferred until after delivery, repeat evaluation for active disease, including chest x-ray, should be performed to confirm that active tuberculosis did not develop in the intervening time between diagnosis and treatment.
The regimen of choice for treatment of LTBI is isoniazid (5 mg/kg up to 300 mg daily) for nine months (table 2). This should be combined with pyridoxine supplementation (25 mg daily) [9].
A six month regimen of daily isoniazid also provides protection but is less desirable
Another choice for treatment of LTBI is rifampin (daily for four months) (table 2) [9]. Rifampin should be used for patients who are intolerant of INH or who are presumed to have infection with INH-resistant, rifampin-sensitive strains of TB.
- 16 yo primip with HIV on Western blot test and 28 weeks pregnant. Risk of transmission to the fetus is:
a) 0%
b) 10%
c) 30%
d) 60%
e) 80%
c) 30%
With multiple retroviral therapy – transmission rate < 2%
With no treatment –
HIV transmission rates were:
●20 percent among 396 women who did not receive antiretroviral drugs
●10 percent for 710 women taking zidovudine alone
●4 percent for 186 women receiving dual antiretroviral drug regimens
●1 percent for those taking three-drug combination antiretroviral drug regimens
- In pregnancy compared to the non-pregnant state:
a) Thyroxine remains the same
b) Free T3 increases
c) Total T3 increases
d) Thyroid binding globulin decreases
c) Total T3 increases
- Serum TBG concentrations rise almost two-fold because oestrogen increases TBG production
- Total serum T4 and T3 concentrations increase. Serum free T4 and T3 concentrations increase slightly, usually within the normal range, and serum TSH concentrations are appropriately reduced
- At routine cardiovascular examination in pregnancy, which of the following may be normal:
a) Diastolic murmur
b) 3rd heart sound
c) Ejection click
d) Renal bruit
b) 3rd heart sound
- *Which of these are true in pregnancy?
a) Normal pregnant requirement of iron in 9mg/day
b) Normal non-pregnant requirement of iron is 4 mg/day
c) Cord ferritin is higher than maternal ferritin
d) 10% of iron is absorbed from non-haem sources
c) Cord ferritin is higher than maternal ferritin
- You see a patient with bipolar disease on Lithium 900mg /day. The risks to the fetus include:
a) CNS abnormalities
b) Cardiac abnormalities
c) Renal anomalies
d) Post-maturity
b) Cardiac abnormalities ( Ebstein barr anomaly)
Normal dose 0.5 – 1gm daily with divided doses
Teratogenicity
o First trimester risk of Ebstein’s anomaly 0.05-0.1%
o Risks of other morphologic and behavioural teratogenicity less clear
o Risk of fetal toxicity cannot be detected by maternal serum lithium level
o Neonatal lithium toxicity can include transient hypothyroidism and tranient nephrogenic diabetes
- Which of the following is associated with intrahepatic cholestasis of pregnancy?
a) RUQ pain
b) High risk of recurrence in future pregnancies
c) Bilirubin levels >10 ( rarely exceeds 6 )
d) Excessive use of antacids
b) High risk of recurrence in future pregnancies
- Number of women who experience transient post-partum blues:
a) 5%
b) 10%
c) 25%
d) 50%
e) 90%
d) 50%
- UTD: 40-80% of women develop transient symptoms D2 to D3
- RCOG: Up to 85% of women
- The most common cause of hyperthryoidism in pregnancy is:
a) Toxic multinodular goitre
b) Graves disease
c) Toxic shock syndrome
d) Iatrogenic
b) Graves disease
- Which change is considered normal/physiological in preg (correct option)
a) Raised Alk phos
b) Decreased albumin
c) Increased urea
a) Raised Alk phos
b) Decreased albumin
- ITP, correct option:
a) Caesarean section is not helpful in known severe fetal thrombocytopenia
b) FBS should not be attempted due to risk of bleeding from puncture site
c) Splenectomy decreases the likelihood of correlation between maternal and fetal platelet counts
d) Maternal antiplatelet ab levels correlate with incidence of neonatal platelet levels
b) FBS should not be attempted due to risk of bleeding from puncture site
- How many women die every day world wide because of a pregnancy related problem?
a) 100
b) 700
c) 1400
d) 3600
b) 700
WHO: 830 every day
A woman with bipolar affective disorder on lithium presents at 11/40. Serum lithium is 1.0 (0.9-1.4). She should be told:
a) Lithium is suspected of causing heart defects
b) To cease lithium now will reduce risk to the baby
c) To reduce dose will reduce risk to baby
d) She should have CVS
e) Should have amniocentesis at 16/40
a) Lithium is suspected of causing heart defects