Mediators of Type I Hypersensitivity

Question 1

examples of Primary (Preformed)

Answer 1

Histamine
Heparin
Eosinophil chemotactic factor of anaphylaxis (ECF-A)
Neutrophil chemotactic factor of anaphylaxis (NCF-A)
Proteases (e.g., tryptase, chymase)

Question 2

Smooth muscle contraction, vasodilation,
increased vascular permeability

Answer 2

Histamine
Heparin

Question 3

Chemotactic for eosinophils

Answer 3

Eosinophil chemotactic factor of anaphylaxis (ECF-A)

Question 4

Chemotactic for neutrophils

Answer 4

Neutrophil chemotactic factor of anaphylaxis (NCF-A)

Question 5

Convert C3 to C3b, stimulate mucus production, activate cytokines

Answer 5

Proteases (e.g., tryptase, chymase)

Question 6

examples of Secondary (Newly Synthesized)

Answer 6

Prostaglandin PGD2
Leukotriene LTB4
Leukotrienes LTC4, LTD4, LTE4
Platelet activating factor (PAF)
Cytokines IL-1, IL-3, IL-4, IL-5, IL-6, IL-9, IL-13, IL-14, IL-16, TNF-α, GM-CSF

Question 7

Vasodilation, increased vascular permeability

Answer 7

Prostaglandin PGD2

Question 8

Increased vascular permeability, bronchoconstriction, mucus secretion

Answer 8

Leukotrienes LTC4, LTD4, LTE4

Question 9

Chemotactic for neutrophils, eosinophils

Answer 9

Leukotriene LTB4

Question 10

Platelet aggregation

Answer 10

Platelet activating factor (PAF)

Question 11

Increase inflammatory cells in area, and
increase IgE production

Answer 11

Cytokines IL-1, IL-3, IL-4, IL-5, IL-6, IL-9, IL-13, IL-14, IL-16, TNF-α, GM-CSF