Mediator And Prinicpal Action

Question 1

Serotonin

Answer 1

Source: platelets

Action; vasodilation, increased vascular permeability

Question 2

Prostaglandins (PGs)

Answer 2

Source: mast cells, leukocytes
Action: vasodilation, fever

Question 3

Leukotrienes

Answer 3

Source: mast cells, leukocytes
Action: similar to histamine but effects last longer. Chemotaxis also

Question 4

Platelet-activating factor

Answer 4

Source: leukocytes, endothelial cells
Actions: vasodilation increased vascular permeability, chemotaxis

Question 5

Reactive oxygen species

Answer 5

Source: leukocytes
Action: kill microbes, damage tissue

Question 6

Nitric acid

Answer 6

Source: endothelium, macrophages
Action: vascular smooth m relaxation; kills microbes

Question 7

Cytokines (TNF, IL-1)

Answer 7

Source: macrophages, lymphocytes, endothelial cells, mast cells
Action: local endothelial activation (adhesion molecule expression) systemic acute- phase response)

Question 8

Cemokines

Answer 8

Source: leukocytes, activated macrophages
Action: leukocyte chemotaxis & activator

Question 9

Complement

Answer 9

Source: plasma (produced in lived)
Action: leukocyte chemotaxis and activation.
Opsonization, vasodilation (mast cell) stimulation

Question 10

Kinins

Answer 10

Source: plasma (produced in liver)
Action: pain

Question 11

Histamine

Answer 11

Source: mast cells, basophils, platelets
Action: vasodilation, increased vascular permeability