MEDgems

Question 1

Type 1 renal tubular acidosis

Answer 1

fail to acidify urine
intravascular metabolic acidosis

profound metabolic acidosis
hypokalaemia
renla stones
alpha intercalated cells c+an’te secrete h+ and resorb K

Question 2

type 2 RTA

Answer 2

moderate met acidosis
hypokalaemia
fail of PTC to reabsorb HC03-

Question 3

type 4 hyperkalaemic RTA

Answer 3

adrenal failure
mild reduction in serum pH
hyperkalaemic
deficient in aldosterone

Question 4

non acute gout
reduces urate levels by increasing FEOU

Answer 4

probenecid

Question 5

______ acts by inhibiting polymerisation of tubulin to reduce migration of neutrophils

Answer 5

colchicine

Question 6

__________ inhibits the enzyme xanthine oxidase to reduce urate synthesis

Answer 6

allopurinol

Question 7

what pH imablance associated with hypokalaemia?

Answer 7

alkalosis

Question 8

low blood pH is associated with _____ plasma potassium concentration

Answer 8

HIGH plasma potassium
acidaemia - hyperkalaemia

Question 9

PCT failure
cannot reabsorb anything
dysfunction

glucosuria
hypophosphataemia
hyperuricaemia

Answer 9

fanconi syndrome

Question 10

causes of fanconi syndrome

Answer 10

congenital
wilsons
tetracyclines
MM
lead

Question 11

lomitapide inhibits?

Answer 11

microsomal triglyceride transfer protein

Question 12

MTP acts on?

Answer 12

blocks VLDL release from liver
> reduced LDL levels

Question 13

albright hereditary osteodystrophy

Answer 13

pseudohypoparathyroidism

short 4/5th metacarpals