Medbear Pancreas and Spleen Flashcards
Describe the embryology of the pancreas
- Developed from the dorsal and ventral buds (with the bile duct), ventral bud rotates around the 2nd part of duodenum, majority of pancreatic duct (duct of Wirsung) from ventral bud and accessory duct (duct of Santorini) from dorsal bud
- Main pancreatic duct - segment of the dorsal duct proximal to dorsal-ventral fusion point
Duct of Wirsung - segment in ventral duct between dorsal-ventral fusion point
Duct of Santorini - portion of the dorsal duct distal to the dorsal-ventral fusion point
Describe the anatomy of the pancreas based on the following heading
- Head
- Neck
- Body
- Tail
- Head = lie within C-shaped concavity of duodenum
- Neck = lie in front of the portal vein and overlie origin of SMV
- Body = runs upwards and to the left across the midline
- Tail = passes forward in the splenorenal ligament, anterior to left adrenal gland contacting hilum of the spleen
State the blood supply of the pancreas
Arterial supply
- Celiac artery give rise to SPLENIC ARTERY (TAIL) and SUPERIOR PANCREATICODUODENAL ARTERY (HEAD)
- Superior mesenteric artery -> INFERIOR PANCREATICODUODENAL ARTERY (HEAD)
Venous drainage (head and uncinated)
- PANCREATICODUODENAL VEINS -> Posterolateral surface of the portal vein
*Splenic artery runs superior to pancreatic body
*Splenic vein runs posterior to pancreatic body
Define acute pancreatitis
- Reversible pancreatic parenchymal damage of varying severity owing to an acute inflammatory disease of the pancreas
Which 3 features are required in the diagnosis of acute pancreatitis?
- Abdominal pain consistent with epigastric pain
- Serum lipase/amylase activity of at least 3X greater than the upper limit of normal
- Characteristic findings of acute pancreatitis on CECT, MRI or trans-abdominal US
State the causes of acute pancreatitis
Hints: I GET SMASHED
- Idiopathic (15-25%)
- Gallstones (40-70%)
- Ethanol (25-35%)
- Trauma
- Steroids
- Mumps and other infections
- Autoimmune (increase in IgG4)
- Scorpion toxin and other toxins
- Hypertriglyceridemia, hypercalcemia (metabolic causes)
- ERCP (2-5%)
- Drugs (1-2%)
Others: Neoplasm, Congenital, Familial Pancreatitis
Explain on the pathophysiology of acute pancreatitis
- Caused by unregulated activation of TRPSIN within pancreatic acinar cells -> activating pro-enzymes leading to AUTO-DIGESTION and inflammatory cascade
How gallstones causes acute pancreatitis?
- Obstruction of the pancreatic duct -> Increased pressure in the pancreatic duct -> EXTRAVASATION of pancreatic juice -> Injury of the gland
- Interstitial edema impairs blood flow to pancreatic cells -> ischemic cellular injury -> activation of pro-enzymes -> destruction of pancreatic acinar cells
How alcohol causes acute pancreatitis?
- Direct toxic effect and/or its metabolites on acinar cells -> gland autodigestive injury
State the (3) common clinical presentation of acute pancreatitis
- Acute and constant pain at the EPIGASTRIC area or RUQ
- Unable to get comfortable when lying supine
- Pain last for several days associated with NAUSEA and VOMITING
State (5) complicated symptoms of acute pancreatitis
- Respiratory failure (e.g dyspnoea secondary to diaphragmatic inflammation, pleural effusion, ARDS)
- Renal failure (e.g OLIGURIA)
- GI failure (e.g nausea, vomiting, abdominal bloatedness)
- Fever +/- hypotension
- SIRS response (e.g tachycardia, tachypnea, fever)
- Obstructive jaundice
*SIRS - Systemic Inflammatory Response Syndrome
What other differential diagnosis you should rule out for a case of acute pancreatitis?
- Gastric cause (PUD, perforated viscus)
- Hepatobiliary cause (hepatitis, GB/CBD disease)
- Medical cause (AMI, DKA, lower lobe pneumonia)
What are the diagnostic investigations (Biochemical) done to confirm a case of acute pancreatitis?
Investigations for diagnosis -> investigation for severity stratification
Diagnostic:
(Levels >3 times the normal upper limit)
- Serum amylase (Normal = 30-100U/L)
- Serum lipase (Normal = 10-140U/L)
Assess severity and prognosticate disease
- Full blood count (Leukocytosis, Hematocrit levels)
- Renal panel, calcium panel, glucose (Assess hydration status and degree of renal impairment, hypocalcemia, hyperglycemia)
- Liver function test (AST, Albumin, LDH)
- ABG (Assess base deficit and arterial oxygenation)
- CRP (>150mg/L within 48 hrs associated with severe pancreatitis)
What are the diagnostic investigations (Imaging) done to confirm a case of acute pancreatitis?
- Erect CXR and supine AXR
- Hepatobiliary US
- CTAP
- MRCP
What to look for in the erect CXR and supine AXR of acute pancreatitis?
Erect CXR
- Air under the diaphragm (Perforated viscus)
- Complete whiteout (ARDS)
Supine AXR -> Look for
- Sentinel loop sign - focal area of adynamic ileus close to an intra-abdominal inflammatory process
- Colon cut-off sign - distended colon from ascending to mid-transverse with narrowing of splenic flexure
- Pancreatic calcification (chronic pancreatitis from alcohol abuse)
State (3) indications for CTAP in a case of acute pancreatitis
- Useful in confirming the diagnosis of pancreatitis if hematological result is inconclusive
- Useful in severely ill patients with suspicion of necrotizing pancreatitis
- Patient with persisting organ failure, signs of sepsis, or deterioration in clinical status 6-10 days after admission
State the (3) categories of the modified CT severity index
- Pancreatic inflammation
- Extra-pancreatic complication
- Pancreatic necrosis
State (3) advantages of MRCP in diagnosing acute pancreatitis
- Higher sensitivity for diagnosis of early acute pancreatitis
- Substitute for CT scan in patients allergic to iodinated contrast and in acute renal failure
- Good for visualizing cholelithiasis, choledocolithiasis, congenital anomalies of the pancreas
According to Atlanta Classification for acute pancreatitis, state the characteristic features of moderate severity.
- Transient organ failure (resolves within 48 hours)
- Local complications or exacerbation of comorbid disease
State Ranson’s criteria (On admission and initial 48 hours)
Hints:
On admission (LEGAL)
Initial 48 hours (CAlvin & HOBBES)
A score of >3 indicates severe pancreatitis
What are the shortfalls of Ranson’s criteria?
- Validated for alcoholic pancreatitis only -> revised Ranson’s criteria is for gallstone pancreatitis
- Cumbersome to wait for 48 hours and difficult to assess for negative fluid balance
State all components of Imrie’s criteria
Hints: PANCREAS
How do we diagnose SIRS?
- Based on temperature, HR, RR, and WBC
Describe the management of acute pancreatitis
Supportive treatment
1. Fluid resuscitation - with CRYSTALLOIDS (lactated ringer)
2. Monitoring (after resuscitating)
3. Pain control with analgesia -> Use opioid analgesia (TRAMADOL) other than morphine. Also, do not give NSAIDs
4. Nutrition
5. Antibiotics
6. Support for organ failure - with presence of organ failure, manage patient in ICU