med surg test 2! Endocrine and integumentary Flashcards
What are four different things that were discussed that have an effect on hormones?
Pain
Emotion
Sexual excitement
Stress
If a hormone acts in the opposite/inverse direction of another hormone, this is what kind of feedback system?
Negative feedback loop
What is an example of a negative feedback loop that was discussed in class?
Blood calcium levels and parathyroid levels
If the blood calcium levels are low in the body, parathyroid hormone will be ____
High
If parathyroid hormone is low in the body, blood calcium will be _____
High
If two hormones rise and fall together (move in the same direction) they are apart of what feedback system
Positive feedback loop
What are the examples of a positive feedback system that was discussed in class?
LH and Estrogen
LH and estrogen _____ and ____ together
RISE and FALL
What kind of hormones go in both directions (I really do not understand this)
Complex hormones
What two systems are super related when it comes to hormones?
Endocrine system and the Nervous system
What is the movement of calcium FROM the bones TO the bloodstream?
Reabsorption
What is the movement of calcium FROM the blood TO the bones for storage?
Absorption
_________ effects the absorption of what Calcium?
Cortisol
Cortisol is ________, so it is increased in the morning and then _________ in the evening
DIURNAL; decreased (peaks again by AM)
When do Cortisol levels need to be drawn?
Early at like 8am, because this is when it is at it’s highest
What two hormones peak during sleep?
Growth hormones and prolactin
What hormones are released in a cyclic fashion over approximately 28 days
Female reproductive hormones
What hormones are secreted from the anterior pituitary?
Prolactin, FSH, ACTH, GH, TSH, and LH
Hormones from the anterior pituitary are “trophic” hormones and are secreted into the ___________
Bloodstream
The posterior pituitary STORES what two hormones?
ADH and Oxytocin
ADH and oxytocin are made where?
In the hypothalamus
What three hormones are secreted from the adrenal cortex
sugar, salt, and sex
Cortisol, aldosterone and androgens
What hormones are released from the adrenal medulla?
Catecholamines (Epi and NorEpi)
What are the targets organs that are associated with the hormones of the hypothalamus?
Thyroid
Kidneys
Bones
Gonads
Mammary glands
Smooth muscles
Tissue
ADH is a ______________
Vasoconstrictor
ADH is AKA “_________” hormones
No pee
ADH stimulates the ____________ of water into the renal tubules
Reabsorption
LOTS of ADH =
LITTLE URINE OUTPUT
LITTLE ADH=
LOTS OF URINE OUTPUT
Increased ADH, little urine output will lead to?
Fluid overload
Decreased ADH, and lots of urine output will lead to
excessive output (Dry Inside)
Disorder when the body has too little ADH
Diabetes Insipidus
Disorder when the body has too much ADH?
SIADH
What hormones stimulates the ejection of milk and the contraction of smooth muscles?
Oxytocin
What inhibits Oxytocin?
Alcohol
Growth hormone targets which body cells?
All of them
What are the normal ranges of GH for a male
4-5
What are the normal ranges of GH in a female
10-18 (We need more because of menstration)
What are the normal ranges of GH after exercise
> 20
What is the diagnostic range of GH seen in acromegaly?
> 50
How is lab testing done for Growth Hormone
- Done with a treadmill test
- NPO night before
- 20-30 minutes of exercise
- lab draw STAT
While looking at GH levels, and they have a heart issue, then what do you do to assess GH levels
They will take 50 grams of PO glucose (because they can’t really do the treadmill thing)
How do you interpret lab draw results for GH?
GH will stay increased in they have acromegaly
What is a common reason why there is a GH increase?
Pituitary tumor
________ occurs BEFORE growth plate closure
Gigantism
_________ occurs AFTER growth plate closure
Acromegaly
What are the manifestations of GH excess
essentially everything keeps growing and changing
Enlarged bony structures
Enlarged soft tissue
Change in shoe size, change in voice, sleep apnea, HTN, cardiomegaly, and joint pain.
What are some ways that GH excess is tested for?
In a normal glucose test, the GH will fall but it won’t if they have too much GH
An MRI will show a pituitary tumor
Increased IGF and GH
Surgery is used to remove a pituitary adenoma if it is <
10 mm
What is the basic outline of the surgery for a pituitary adenoma?
- Make incision of upper lip and gingiva
- Approach sella turcica thru the floor of the nose and sphenoid sinuses
- TRY TO ONLY REMOVE TUMOR AND NO GLAND
When a patient is having surgery for their pituitary adenoma removal, they surgeon had to remove the whole gland, what would the lifestyle change be?
He would need replacement hormones for life
(ADH, CORTISOL, THYROID, SEX HORMONES)
What are the 6 pre-op considerations before a pituitary adenoma surgery
Bacitracin nose drops
Education about mouth breathing (post-op their nose will be packed)
They need oral care Q4 hours 6x daily
Avoid coughing, sneezing, and Valsalva maneuvers
Cluster care; Don’t stimulate
Watch for clear liquid and test for CSF
What are the post-op considerations for a patient who just had a pituitary adenoma removed?
- Increase HOB to decrease HA
- Oral care Q 4 hours
- No brushing teeth for 10 days (suture line)
- Test any drainage for CSF
What are some additional post-op considerations for a pituitary adenoma removal?
- Persistent or severe generalized or supraorbital HA can indicate spinal fluid leakage into sinuses (usually resolves in 72 hours with HOB elevated and bed rest)
- Possible daily spinal taps to decrease pressure and to help stop leaks
- IV abx: decreases risk of infection if persistent leak or > 72 hours after surgery
What is used in conjunction with surgery for large pituitary adenomas?
Radiation therapy
What is the nursing care for radiation therapy?
Hold overnight for observation
Monitor VS
Monitor I and O
Neuro checks
What are possible complications after radiation therapy?
N/V, HA, Seizures, DI, or SIADH (Because of a change in sodium levels)
What are the drug therapies that can be used for Pituitary adenomas
Dopamine agonist (decreased GH levels)
Somatostatin (Decreases GH levels)
What is a decrease in one or more pituitary hormone?
Hypopituitarism
What are the causes for primary hypopituitarism?
Developmental, AI disorders, infections, vascular disease and destruction of a gland
What are the manifestations of primary hypopituitarism?
Weakness, fatigue, HA, dry skin, decreased stress tolerance, mental slowness, orthostatic hypotension, blindness and growth retardation
What is the post partum syndrome that affects the pituitary gland?
Sheehan’s syndrome
What are risk factors for Sheehan’s syndrome?
history of hemorrhage
History of hypoxemic episodes during delivery
What are manifestations of Sheehan’s syndrome?
Scant or Irregular menses
Decreased secondary sex characteristics
Hypothyroidism s/sx
Glucocorticoid insufficiency s/sx
Pituitary dwarfism is when there is decreased GH levels, how is this fixed?
Give GH
What is the disorder caused by too much ADH and results in urine retention, but there is normal renal function?
SIADH
Manifestations of SIADH?
- Serum hypoosmolality
- Hyponatremia and Hypochloremia
-Weight loss (if you - edema)
Nursing care for SIADH?
- Declomycin (blocks ADH)
- Fluid restriction 800-1000 cc/day
- 3-5% hypertonic saline
- Daily weight
- Lasix-> If there is an intravascular overload
- Albumin and then Lasix –> If extracellular overload
What is a normal serum osmolality?
285-295
What is the normal urine specific gravity?
1.005-1.030
If a patient has a high specific gravity, their urine will be ______
Dark/amber
If a patient has a low serum osmolality, their urine will be ______
Clear
In a patient with SIADH, their serum osmolality will ___ and their specific gravity will be ____
Serum osmolality will be LOW because there is fluid overload
Specific gravity will be HIGH because they are putting out so little urine
Diagnostic Lab Tests for SIADH
Serum Sodium less than 134-135
Serum Osmolality is less than 280
Urine Specific Gravity greater than 1.025-1.030
A patient has Diabetes Insipidus, you will want to make them a priority and see them first, WHY?
Because it can cause clinically significant electrolyte abnormalities.
What are the clinical manifestations of diabetes insipidus
Polyuria (5-20 L/day) and polydipsia
Urine specific gravity less than 1.005 (diluted)
Elevated serum osmolality greater than 295 (concentrated)
Fatigue, nocturia, and weakness
Central DI is _________ and there is increased ADH synthesis (in the hypothalamus) or release (in the pituitary)
Nerogenic
Nephrogenic DI is when the _______ do not respond to ADH like they are supposed to
KIDNEYS
Psychogenic DI is when there is a ______ disorder or a lesion in the thirst center
Psych
Nursing care for Diabetes Insipidus?
- Vasopressin- mimics ADH
- IV D5W and gluc checks
- Thiazide diuretics (nephrogenic)
- UA to assess specific gravity
- Daily weight and I&Os
What is used to determine the cause of DI?
Water deprivation Test
Steps to a water deprivation test
- Hold all fluids at midnight and get baseline SG and osmolality
- Take 3 postural BP per hour/ hourly urine analysis
- Weights at hours 4,6,7, and 8
- Give IV ADH
After a water deprivation test, if the urine SG and SO are normal it is _______
Psych; they need to stop drinking so much
After a water deprivation test, is the urine SG and SO are greater than 300 it is _______ and they need ___
Central; they need ADH
After a water deprivation test, if there is no or very little response, it is ________
Nephrogenic; total kidney issue so messing with ADH will do nothing
What is the normal T4 levels?
4.6-11
What are the normal T3 levels?
70-204
What are the normal TSH levels?
0.4-4.2
What is the hypermetabolism because of an excess of T3, T4, or both
Thyrotoxicosis
What is when there are antibodies that develop antigens to fight against the thyroid (TSAbs) and they produce more thyroid hormones
Hyperthyroidism/ Graves Disease
What is the kind of hyperthyroidism that nodules secrete extra thyroid hormones and a toxic goiter
Nodular goiter
Nodular goiter can be caused after what?
A stressful event like a car crash, having a baby, chronic illness etc.
What are the diagnostic tests that are seen in hyperthyroidism?
High T3 and T4 and low TSH
What is the most sensitive indicator of thyroid function?
Free T4