Med Onc

Question 1

___ and ____ are high risk for colon cancer.

Answer 1

Ulcerative colitis and IBS

Question 2

What CA can radon cause?

Answer 2

lung

Question 3

What is DNA shearing?

Answer 3

double strand breaks

Question 4

How many mutations, at a minimum, are needed to cause cancer?

Answer 4

5-6

Question 5

Which is the CA that arises from only 1 mutation instead of the usual 6? How do we know this?

Answer 5

CML; Gleevac can cure the dz

Question 6

Why do xrays cause leukemias and not solid tumors?

Answer 6

blood cells do not adhere to one another and therefore don’t need to escape their confines- they are a few steps ahead in carcinogenesis

Question 7

The associations of cadherins with one another is strongly affected by which molecule?

Answer 7

Ca++

Question 8

The associations of _________ with one another is strongly affected by Ca++.

Answer 8

cadherins

Question 9

______ bind the cytoskeleton of one cell to that of its

neighbors, forming a mechanical unit.

Answer 9

Cadherins

Question 10

What are the 2 main types of MMPs?

Answer 10

stromelysins and collagenases

Question 11

What are MMPs important for?

Answer 11

both normal tissue morphogenesis and remodeling

Question 12

What is the sentinel lymph node?

Answer 12

the first draining lymph node- first node involved