Med Chem Cephalosporins

Question 1

What is the MOA of cephalosporins?

A. Degrades the Lipopolysaccharide layer of gram negative and/or gram positive bacteria

B. Inhibits transpeptidase (transamidase) from forming the cross-linking of the peptidoglycan wall

C. Inhibits the production of transpeptidase by the bacterial cell and prevents the cross-linking of the petidoglycan wall

D. None of the above

Answer 1

B

Same MOA as penecillins

Question 2

T/F Cephalosporin antibiotics have similar allergic reactions to penicillins but occurs less frequently

Answer 2

T

Question 3

Patient TJ has had a Type I (IgE-mediated) hypersensitivity reaction when taking penicillin in the past. Is it ok for this patient to receive a cephalosporin antibiotic for future treatment?

A. Yes

B. No

Answer 3

B

Cephalosporins are B-lactam antibiotics just like penicillins are and when someone experiences a Type-I hypersensitivity reaction they should not receive any B-lactam antibiotics again.

Question 4

Patient CJ has experienced an allergic reaction to penicillin that was mild with delayed onset. The doctor suggests that he can still receive certain cephalosporin antibiotics for future treatment. Is the doctor correct?

A. Yes, certain cephalosporins may be given when a patient has had a mild and/or delayed allergic reaction to penicillin.

B. No, any type of allergic reaction despite being mild and/or delayed to penicillins dicatates that a patient should never receive B-lactam antibiotics in the future.

Answer 4

A

Question 5

What is the structural moeity of cephalosporin antibiotics?

A. Cefem

B. Penam

C. Carbapenam

D. Monobactam

Answer 5

A

Question 6

What is the name of the blue group in the cefem moeity?

A. Aminobenzene

B. Trihydroaminobenzine

C. Dihydrothiazine

D. None of the above

Answer 6

C

Dihydro- one less double bond adds two hydrogens=dihydro

Thi- sulfur (thiol)

Azine-Nitrogen (azole)

Dihydrothiazine ring

Question 7

The structure circled in red is known as MTT and if it is present in a cephalosporin antiibotic it can cause: (Select All)

A. Hypoprothrombinemia (low pro-thrombin)

B. Increased platelet aggregation

C. Disulfiram reaction

D. Color-blindness

Answer 7

A, C

Question 8

What does the structure MTT stand for?

A. Methylthioltransferase

B. Methylthiotetrazole

C. Methyltetrathiole

D. None of the above

Answer 8

B

Methyl- Methyl group on the nitrogen

Thio- SH group on the left

Tetra- 4

Azole- nitrogen

Methylthiotetrazole

Question 9

Which of the following cephalosporin SARs is correct for the portion circled in red?

A. NH2 group will improve acid stability and make it orally active (when converted to NH3+)

B. NH2 group will improve