mechanisms of disease: blood disorders

Question 1

______________________________ disorders
1. _______________ = loss of total oxygen-carrying capacity by the RBCs due to either a decrease of hemoglobin or a decrease in RBCs

Answer 1

RBC

Anemia

Question 2

RBC disorders
_____________________ anemia occurs when the body slows or stops the formation of new RBCs (sometimes due to chemicals or radiation

Answer 2

Aplastic

Question 3

______________________ anemia is a decrease in RBCs due to B12 deficiency

Answer 3

pernicious

Question 4

_______________ deficiency anemia is a decrease in RBCs due to a folic acid (B9) deficiency

Answer 4

folate

Question 5

Acute ____________________ anemia due to hemorrhaging

Answer 5

blood loss

Question 6

Anemia of __________________ disease (e.g. cancer)

Answer 6

chronic

Question 7

___________ deficiency anemia due to a decrease in hemoglobin

Answer 7

iron

Question 8

_____________________ anemia is due to a genetic mutation in the hemoglobin

1) ______________________ anemia has a mutation in the β chain
2) _____________________ has mutations in both the α and β chains

Answer 8

Hemolytic
sickle cell
Thalassemia

Question 9

___________________________ = excess of RBCs which can result in the thickening and slowing of blood and an increased risk for blood clots

Answer 9

Polycythemia

Question 10

WBC disorders
____________________
a. under ____________ WBCs/mm3
b. an example is acquired immune deficiency syndrome (__________)

Answer 10

Leukopenia
5,000
AIDS

Question 11

_____________________________

a. abnormally high WBC count that is over _______________ WBCs/mm3
b. an example _______________

Answer 11

Leukocytosis
10,000
leukemia

Question 12

Clotting Disorders
____________________ clotting
a. Thrombus and _______________________ (clot stays in place of origin)
b. _________________ and embolism (clot dislodges and moves to other parts of the body)

Answer 12

excessive
thrombosis
embolus

Question 13

________________ to clot

a. ______________________ results from the absence of blood clotting factors
b. __________________________ results from a decrease in platelet counts

Answer 13

failure
hemophilia
thrombocytopenia