Blood Clotting

Question 1

Blood Clotting (__________________________)

Answer 1

Coagulation

Question 2

Mechanism of ______________________________
1. Extrinsic clotting pathway starts with damaged tissue and ends with production of an enzyme named prothrombinase (__________________________________________)

Answer 2

blood clotting

prothrombin activator

Question 3

Intrinsic clotting pathway starts with damaged endothelial cells contacting platelets and ends with production of _________________________

Answer 3

prothrombinase

Question 4

Common clotting _________________

a. Prothrombin activator converts prothrombin to _________________________
b. Thrombin is an enzyme that converts _______________________ to fibrin for the clot

Answer 4

pathway
thrombin
fibrinogen

Question 5

Conditions that ______________ clotting in intact vessels

	1. \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ endothelium 2. Presence of \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ (e.g., heparin)

Answer 5

oppose
smooth
antithrombins

Question 6

Conditions that ________________ clotting

	1. \_\_\_\_\_\_\_\_\_\_\_\_ places on endothelium
	2. Abnormally \_\_\_\_\_\_\_\_\_\_\_ blood flow

Answer 6

hasten
rough
slow

Question 7

Clot dissolution (\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_) 
1.	Naturally occurring \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ can be activated to form plasmin, which dissolves clots.

Answer 7

fibrinolysis

plasminogen

Question 8

Bacteria produce ___________________________ chemicals to enhance their invasion. These include strepto-kinase and t-PA, both of which have medical applications

Answer 8

clot dissolving