Mechanisms/Drug Class

Question 1

What is the mechanism of action of the suppressors of leukocyte recruitment and activation?

Answer 1

Interrupt inflammatory pathways that cause inflammation in a gouty joint

Question 2

colchicine

Answer 2

suppressor of leukocyte recruitment and activation

Question 3

ibuprofen

Answer 3

suppressor of leukocyte recruitment and activation

Question 4

indomethacin

Answer 4

suppressor of leukocyte recruitment and activation

Question 5

prednisone

Answer 5

suppressor of leukocyte recruitment and activation

Question 6

methylprednisolone

Answer 6

suppressor of leukocyte recruitment and activation

Question 7

What is the mechanism of action of the inhibitors of uric acid synthesis?

Answer 7

Inhibit xanthine oxidase, the enzyme that converts hypoxanthine to xanthine and xanthine to uric acid; decreased uric acid levels lead to less urate crystal formation

Question 8

allopurinol

Answer 8

inhibitor of uric acid synthesis

Question 9

oxypurinol

Answer 9

inhibitor of uric acid synthesis

Question 10

febuxostat

Answer 10

inhibitor of uric acid synthesis

Question 11

sulfinpyrazone

Answer 11

Increases uric acid secretion

Question 12

probenecid

Answer 12

Increases uric acid secretion

Question 13

losartan

Answer 13

Increases uric acid secretion

Question 14

What is the mechanism of action of agents that enhance uric acid metabolism?

Answer 14

These are enzymes that convert sparingly soluble irate to more soluble allantoin

Question 15

rasburicase

Answer 15

enhances uric acid metabolism

Question 16

pegloticase

Answer 16

enhances uric acid metabolism