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Pharmacology Chapter 42 > Mechanisms/Drug Class > Flashcards

Mechanisms/Drug Class Flashcards

1
Q

What is the mechanism of action of NSAIDs?

A

Inhibit cyclooxygenase, COX-1 and COX-2, decreasing the biosynthesis of downstream eicosanoids and thereby limiting the inflammatory response

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2
Q

aspirin

A

NSAID

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3
Q

ibuprofen

A

NSAID (propionic acid)

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4
Q

naproxen

A

NSAID (propionic acid)

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5
Q

ketoprofen

A

NSAID (propionic acid)

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6
Q

flurbiprofen

A

NSAID (propionic acid)

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7
Q

indomethacin

A

NSAID (acetic acid)

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8
Q

sulindac

A

NSAID (acetic acid)

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9
Q

etodolac

A

NSAID (acetic acid)

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10
Q

etodolac

A

NSAID (acetic acid)

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11
Q

diclofenac

A

NSAID (acetic acid)

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12
Q

keterolac

A

NSAID (acetic acid)

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13
Q

piroxicam

A

NSAID (oxicam)

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14
Q

mefenamate

A

NSAID (fenamates)

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15
Q

meclofenamate

A

NSAID (fenamates)

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16
Q

nabumetone

A

NSAID (ketone)

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17
Q

What is the mechanism of action of acetaminophen?

A

Weak inhibitor of peripheral cyclooxygenases; predominant effect may be inhibition of COX-3 in the CNS

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18
Q

What is the mechanism of action of COX-2 selective inhibitors?

A

Selective inhibition of COX-2

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19
Q

celecoxib

A

COX-2 selective inhibitor

20
Q

What is the mechanism of action of glucocorticoids?

A

Inhibit COX-2 action and prostaglandin biosynthesis by inducing lipocortins, activating endogenous anti-inflammatory pathways and other mechanisms (phospholipase A2 inhibition)

21
Q

prednisone

A

glucocorticoid

22
Q

prednisolone

A

glucocorticoid

23
Q

methylprednisolone

A

glucocorticoid

24
Q

dexamethasone

A

glucocorticoid

25
Q

What is the mechanism of action of cytokine antagonists?

A

Inhibition of TNF-alpha (by etanercept, infliximab, adalimumab, golimumab, and certolizumab); inhibit IL-1 (by anakinra)

26
Q

etanercept

A

cytokine antagonist

27
Q

infliximab

A

cytokine antagonist

28
Q

adalimumab

A

cytokine antagonist

29
Q

golimumab

A

cytokine antagonist

30
Q

certolizumab

A

cytokine antagonist

31
Q

What is the mechanism of action of prostanoid mimetics?

A

Prostanoid receptor agonists

32
Q

alprostadil

A

prostanoid mimetic

33
Q

misoprostol

A

prostanoid mimetic

34
Q

carboprost

A

prostanoid mimetic

35
Q

latanoprost

A

prostanoid mimetic

36
Q

bimatoprost

A

prostanoid mimetic

37
Q

travoprost

A

prostanoid mimetic

38
Q

epoprostenol

A

prostanoid mimetic

39
Q

What is the mechanism of action of thromboxane antagonists?

A

Inhibit thromboxane synthase or antagonize thromboxane receptor (investigational agents)

40
Q

dazoxiben

A

thromboxane antagonist

41
Q

pirmagrel

A

thromboxane antagonist

42
Q

ridogrel

A

thromboxane antagonist

43
Q

What is the mechanism of action of lipoxygenase inhibitors?

A

Inhibits 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid

44
Q

zileuton

A

lipooxygenase inhibitor

45
Q

What is the mechanism of action of leukotriene receptor antagonists?

A

Selective antagonists of the cysteinly leukotriene (CysLT) type-1 receptor

46
Q

anakinra

A

cytokine antagonist

Pharmacology Chapter 42 (4 decks)

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