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Pharm 34X > Mechanisms > Flashcards

Mechanisms Flashcards

1
Q

Muscarine

A

mAChR agonist

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2
Q

Nicotine

A

nAChR agonist

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3
Q

Amphetamine

A

indirect sympathomimetic
release of catecholamines from vesicles

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4
Q

Methylphenidate

A

indirect sympathomimetic
release of catecholamines from vesicles

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5
Q

Tyramine

A

indirect sympathomimetic
release of catecholamines from vesicles

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6
Q

Cocaine

A

indirect sympathomimetic
prevents uptake of catecholamines

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7
Q

TCA

A

indirect sympathomimetic
prevents uptake of catecholamines

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8
Q

Atropine

A

mAChR antagonist

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9
Q

Scopolamine

A

mAChR antagonist
treatment for vestibular disturbances

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10
Q

Carbachol

A

AChR agonist

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11
Q

Malathion

A

anticholinesterase

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12
Q

Succinylcholine

A

nAChR antagonist

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13
Q

Isoprenaline

A

β agonist

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14
Q

Dobutamine

A

β1 agonist

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15
Q

Salbutamol

A

tx for asthma
β2 agonist

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16
Q

Phenylephrine

A

tx for nasal congestion
α1 agonist

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17
Q

Phentolamine

A

α antagonist

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18
Q

Prazosin

A

α1 antagonist

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19
Q

Metoprolol

A

β1 selective blocker

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20
Q

Propanolol

A

non selective β blocker

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21
Q

Clonidine

A

α2 agonist

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22
Q

Yohimbine

A

α2 antagonist

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23
Q

Salmeterol

A

tx for asthma
long lasting β2 agonist

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24
Q

Formoterol

A

tx for asthma
long lasting β2 agonist

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25
Theophylline
tx for asthma bronchodilator inhibits phosphodiesterase = ↑ cAMP
26
Montelukast
tx for asthma bronchodilator CysLT1 antagonist
27
Zafirlukast
tx for asthma bronchodilator CysLT1 antagonist
28
Beclometasone
tx for asthma inhaled glucocorticoid = anti-inflammatory
29
Budenoside
tx for asthma inhaled glucocorticoid = anti-inflammatory
30
Fluticasone
tx for asthma inhaled glucocorticoid = anti-inflammatory
31
Ciclesonide
tx for asthma inhaled glucocorticoid = anti-inflammatory
32
Prednisolone
tx for asthma oral glucocorticoid = anti-inflammatory
33
Omalizumab
tx for asthma monoclonal anti-IgE antibody
34
Levodopa
tx for Parkinson's Dopamine precursor = enhance synthesis of DA in striatum
35
Carbidopa
tx for Parkinson's peripheral inhibitor of dopa decarboxylase
36
Bromocriptine
tx for Parkinson's D2 partial agonist
37
Pramipexole
tx for Parkinson's high affinity D3 agonist
38
Ropinirole
tx for Parkinson's high affinity D2 agonist metabolized by CYP1A2
39
Selegiline
tx for Parkinson's MAO (B) inhibitor
40
Rasagiline
tx for Parkinson's MAO (B) inhibitor more potent than Selegiline
41
Entacapone
tx for Parkinson's peripheral COMT inhibitor
42
Tolcapone
tx for Parkinson's central + peripheral COMT inhibitor
43
Benztropine
tx for Parkinson's antimuscarinic = ↓ excitatory actions of cholinergic neurons
44
Biperiden
tx for Parkinson's antimuscarinic = ↓ excitatory actions of cholinergic neurons
45
Amantadine
tx for Parkinson's ↑ availability of dopamine presynaptic: ↑ biosynthesis postsynaptic: ↑ D2 receptor activation
46
Butyrophenone
antipsychotic causes Parkinson sx
47
Phenothiazine
antipsychotic causes Parkinson sx
48
Reserpine
causes Parkinson sx through depletion of brain dopamine
49
MPTP
causes irreversible Parkinson sx through damage of DA neurons in nigrostriatal tract
50
Clonazepam
anti-seizure drug benzodiazepine myoclonic - opening of Cl- channels = enhance activation of GABA(A) receptors
51
Phenobarbital
anti-seizure drug (back-up tx) barbiturate - opening of Cl- channels = enhance activation of GABA(A) receptors - inhibits NMDA receptors **
52
Tiagabine
anti-seizure drug (back-up tx) - inhibit GAT1 GABA transporter = ↓ reuptake of GABA
53
Vigabatrin
anti-seizure drug (back up tx) - inhibit GABA-T catabolism of GABA = ↑ GABA availability
54
Felbamate
anti-seizure drug (back up tx) - facilitates inhibitory actions of GABA - inhibits NMDA receptors
55
Topiramate
anti-seizure drug (back up tx) - facilitates inhibitory actions of GABA - inhibits NMDA receptors
56
Valproate
anti-seizure drug tonic-clonic & focal myoclonic absence - facilitates inhibitory actions of GABA - sodium channel blocker - blocks GABA transaminase - promotes effect on NMDA receptor **
57
Phenytoin
anti-seizure drug tonic-clonic & focal - sodium channel blocker **
58
Carbamazepine
anti-seizure drug tonic-clonic & focal - sodium channel blocker **
59
Lamotrigine
anti-seizure drug tonic-clonic & focal myoclonic absence - sodium channel blocker = inhibits release of glu + asp **
60
Pregabalin
anti-seizure drug - calcium channel blocker (T-type low voltage activity in thalamus)
61
Gabapentin
anti-seizure drug (back up tx) - calcium channel blocker (T-type low voltage activity in thalamus)
62
Perampanel
anti-seizure drug (back up tx) - inhibits AMPA receptors
63
Ethosuximide
anti-seizure drug absence
64
Flumazenil
tx of benzodiazepine overdose GABA(A) antagonist
65
Mepolizumab
tx for eosinophilic asthma IL-5 inhibitor
66
Timolol
tx for glaucoma topical β blocker = ↓ secretion from ciliary body
67
Pilocarpine
tx for glaucoma M3 agonist = ↑ ciliary contraction
68
Echothiphate
tx for glaucoma anticholinesterase = ↑ ciliary contraction
69
Physostigmine
tx for glaucoma anticholinesterase = ↑ ciliary contraction
70
Aproclonidine
tx for glaucoma (like adrenaline) vasoconstrictor = ↓ blood flow = ↓ secretion
71
Anadamide
tx for glaucoma endogenous cannabinoid → binds CB1 = Gi → ↓ IOP
72
Ipratropium
tx for COPD inhaled anticholinergic (nAChR) = inhibits M3 bronchoconstriction
73
Tiotropium
tx for COPD longer lasting inhaled anticholinergic = inhibits M3 bronchoconstriction
74
Roflumilast
tx for COPD long acting inhibitor of phosphodiesterase 4 = ↓ inflammation

Pharm 34X (8 decks)

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