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Antibiotics > Mechanism Of Action > Flashcards

Mechanism Of Action Flashcards

1
Q

How does some antibiotics affect the cell wall to kill bacteria?

A

Inhibits enzymes that synthesizes cell wall

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2
Q

Explain how lowering peptoglycon synthesis kill bacteria

A

Cell walls are made of peptoglycon so affecting its synthesis breaks cell wall

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3
Q

Lowers Peptoglycon Synthesis

A

Vancomycin and Fosfomycin

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4
Q

Vancomycin

A

Lowers Peptoglycon synthesis

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5
Q

Fosfomycin

A

Lowers Peptoglycon synthesis

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6
Q

How does lowering the cross linking peptoglycon kill bacteria ?

A

Enables the cell wall to not form or become more permeable

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7
Q

Lowers cross linking of peptoglycon

A

Natural Penicillin, Antisphylococcal PNC, Amino-PCN, Antipseudomonal

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8
Q

Natural Penicillin

A

Lowers cross linking of peptoglycon

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9
Q

Antistophylococcal PCN

A

Lowers cross linking of peptoglycon

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10
Q

Amino PCN

A

Lowers cross linking of peptoglycon

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11
Q

Antipseudomonal

A

Lowers cross linking of peptoglycon

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12
Q

PCN G

A

Natural PCN

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13
Q

PCN V

A

Natural PCN

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14
Q

Oxacillin

A

Antisphylococcal PCN

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15
Q

Nafcillin

A

Antisphylococcal PCN

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16
Q

Diccoxacillin

A

Antisphylococcal PCN

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17
Q

Amoxicillin

A

Amino PCN

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18
Q

Ampicillin

A

Amino PCN

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19
Q

Piperacillin

A

Antipseudomonal

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20
Q

Cephalosporins 1st gen

A

Cefazolin and Cephahexin

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21
Q

Cephalosporins 2nd gen

A

Cefaclor, Cefoxitin, and Cefototan

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22
Q

Cephalosporins 3rd gen

A

Ceftriaxone, Cefotaxime, and Ceftazadime

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23
Q

Cephalosporins 4th gen

A

Cefepime

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24
Q

Cephalosporins 5th gen

A

Ceftaroline

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25
Carbapenems
Doripenem, Imipenem, Meropenem, and Ertrapenem
26
Doripenem
Carbapenems
27
Imipenem
Carbapenem
28
Meropenem
Carbapenem
29
Ertrapenem
Carbapenem
30
Monobactams
Aztreonam
31
B-Lactamase Inhibitors
Clavulanate, Sulbactam, Tazobactam, Avibactam
32
Clavulanate
Amoxicillin
33
Sulbactam
Ampicillin
34
Tazobactam
Piperacillin
35
Avibactam
Ceftazadime
36
How does breaking the cell membrane integrity kill bacteria?
Make the membrane more permeable enabling substances to enter the cell killing the bacteria
37
Antibiotics that affect cell membrane
Daptomycin and Polymyxins
38
Daptomycin
Cell membrane integrity
39
Polymyxins
Cell membrane integrity
40
Antibiotics that affect Folic Acid Pathway
Sulfamethoxazole and trimethoprim
41
How does antibiotics affect DNA integrity
It synthesizes reactive energy oxygen species affecting DNA integrity
42
DNA Integrity
Metronidazole
43
DNA Integrity
Nitrofurantolin
44
Affects mRNA synthesis
Rifamdin
45
How does antibiotics affect DNA gyrase function?
Affects topoisomerase which affects the topology of cell enabling it to continue to cut and realign DNA
46
Antibiotics that affect gyrase function
Fluroquinolones
47
1st gen Fluroquinolones
Ciprofcoxacin
48
2nd gen Fluroquinolones
Leuofloxacin, Geroifloxacin, Moxifloxacin
49
Antibiotics that affect the 50 S Ribosome Subunit
Macrolides, Clindamycin, Chloramphenicol, Linezolio
50
Macrolides
Azithromycin, Erythromycin, Clarithromycin
51
Clindamycin
50 S Ribosome Subunit
52
Chloramphenicol
50 S Ribosome Subunit
53
Linezolio
50 S Ribosome Subunit
54
30 S Ribosome Subunit
Aminoglycosides and Tetracyclines
55
Aminoglycosides
30 S Ribosome Subunit
56
Tetracyclines
30 S Ribosome Subunit
57
Antibiotics categorized as Aminoglycosides
Tombramycin, Amikacin, and Gentamicin
58
Antibiotics categorized as tetracyclines
Doxycycline and Tetraxycline
59
Tobramycin
Aminoglycosides
60
Amikacin
Aminoglycosides
61
Gentamicin
Aminoglycosides
62
Doxycycline
Tetracyclines
63
Tetracycline
Tetracyclines

Antibiotics (2 decks)

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