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Antibiotics > Mechanism Of Action > Flashcards

Mechanism Of Action Flashcards

1
Q

How does some antibiotics affect the cell wall to kill bacteria?

A

Inhibits enzymes that synthesizes cell wall

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2
Q

Explain how lowering peptoglycon synthesis kill bacteria

A

Cell walls are made of peptoglycon so affecting its synthesis breaks cell wall

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3
Q

Lowers Peptoglycon Synthesis

A

Vancomycin and Fosfomycin

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4
Q

Vancomycin

A

Lowers Peptoglycon synthesis

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5
Q

Fosfomycin

A

Lowers Peptoglycon synthesis

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6
Q

How does lowering the cross linking peptoglycon kill bacteria ?

A

Enables the cell wall to not form or become more permeable

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7
Q

Lowers cross linking of peptoglycon

A

Natural Penicillin, Antisphylococcal PNC, Amino-PCN, Antipseudomonal

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8
Q

Natural Penicillin

A

Lowers cross linking of peptoglycon

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9
Q

Antistophylococcal PCN

A

Lowers cross linking of peptoglycon

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10
Q

Amino PCN

A

Lowers cross linking of peptoglycon

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11
Q

Antipseudomonal

A

Lowers cross linking of peptoglycon

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12
Q

PCN G

A

Natural PCN

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13
Q

PCN V

A

Natural PCN

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14
Q

Oxacillin

A

Antisphylococcal PCN

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15
Q

Nafcillin

A

Antisphylococcal PCN

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16
Q

Diccoxacillin

A

Antisphylococcal PCN

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17
Q

Amoxicillin

A

Amino PCN

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18
Q

Ampicillin

A

Amino PCN

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19
Q

Piperacillin

A

Antipseudomonal

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20
Q

Cephalosporins 1st gen

A

Cefazolin and Cephahexin

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21
Q

Cephalosporins 2nd gen

A

Cefaclor, Cefoxitin, and Cefototan

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22
Q

Cephalosporins 3rd gen

A

Ceftriaxone, Cefotaxime, and Ceftazadime

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23
Q

Cephalosporins 4th gen

A

Cefepime

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24
Q

Cephalosporins 5th gen

A

Ceftaroline

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25
Q

Carbapenems

A

Doripenem, Imipenem, Meropenem, and Ertrapenem

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26
Q

Doripenem

A

Carbapenems

27
Q

Imipenem

A

Carbapenem

28
Q

Meropenem

A

Carbapenem

29
Q

Ertrapenem

A

Carbapenem

30
Q

Monobactams

31
Q

B-Lactamase Inhibitors

A

Clavulanate, Sulbactam, Tazobactam, Avibactam

32
Q

Clavulanate

A

Amoxicillin

33
Q

Sulbactam

A

Ampicillin

34
Q

Tazobactam

A

Piperacillin

35
Q

Avibactam

A

Ceftazadime

36
Q

How does breaking the cell membrane integrity kill bacteria?

A

Make the membrane more permeable enabling substances to enter the cell killing the bacteria

37
Q

Antibiotics that affect cell membrane

A

Daptomycin and Polymyxins

38
Q

Daptomycin

A

Cell membrane integrity

39
Q

Polymyxins

A

Cell membrane integrity

40
Q

Antibiotics that affect Folic Acid Pathway

A

Sulfamethoxazole and trimethoprim

41
Q

How does antibiotics affect DNA integrity

A

It synthesizes reactive energy oxygen species affecting DNA integrity

42
Q

DNA Integrity

A

Metronidazole

43
Q

DNA Integrity

A

Nitrofurantolin

44
Q

Affects mRNA synthesis

45
Q

How does antibiotics affect DNA gyrase function?

A

Affects topoisomerase which affects the topology of cell enabling it to continue to cut and realign DNA

46
Q

Antibiotics that affect gyrase function

A

Fluroquinolones

47
Q

1st gen Fluroquinolones

A

Ciprofcoxacin

48
Q

2nd gen Fluroquinolones

A

Leuofloxacin, Geroifloxacin, Moxifloxacin

49
Q

Antibiotics that affect the 50 S Ribosome Subunit

A

Macrolides, Clindamycin, Chloramphenicol, Linezolio

50
Q

Macrolides

A

Azithromycin, Erythromycin, Clarithromycin

51
Q

Clindamycin

A

50 S Ribosome Subunit

52
Q

Chloramphenicol

A

50 S Ribosome Subunit

53
Q

Linezolio

A

50 S Ribosome Subunit

54
Q

30 S Ribosome Subunit

A

Aminoglycosides and Tetracyclines

55
Q

Aminoglycosides

A

30 S Ribosome Subunit

56
Q

Tetracyclines

A

30 S Ribosome Subunit

57
Q

Antibiotics categorized as Aminoglycosides

A

Tombramycin, Amikacin, and Gentamicin

58
Q

Antibiotics categorized as tetracyclines

A

Doxycycline and Tetraxycline

59
Q

Tobramycin

A

Aminoglycosides

60
Q

Amikacin

A

Aminoglycosides

61
Q

Gentamicin

A

Aminoglycosides

62
Q

Doxycycline

A

Tetracyclines

63
Q

Tetracycline

A

Tetracyclines

Antibiotics (2 decks)

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