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Arrhythmias > Mechanism of Action > Flashcards

Mechanism of Action Flashcards

1
Q

Class 1a Antiarrhymics

A

EX: Procainamide, Quinidine, Disopyramide

Na channel blockers
blocks phase 0
Reduces the force of ventricular contraction
* use CAUTION in cardiac disease = proarrhythmic

negative inotrope (decrease force of contraction)

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2
Q

Class 1b Antiarrhythmics

A

EX: Lidocaine, Mexiletine

Na channel blockers blocks phase 0
Reduces the force of ventricular contraction
*use CAUTION in cardiac disease = proarrhythmic

negative inotrope (decrease force of contraction)

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3
Q

Class 1c Antiarrhythmics

A

EX: Flecainide, Propafenone

Na channel blockers - block phase 0
Reduces ventricular contraction
*use CAUTION in cardiac disease = proarrhythmic

negative inotrope (decrease force of contraction)

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4
Q

Class II Antiarrhythmia

A

Beta blockers
block the sympathetic activity that can trigger arrythmias; used primarily to slow the ventricular rate in Atrial Fibrillation

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5
Q

Class III Antiarrhythmics

A

EX: Dronedarone, Dofetilide, Sotalol, Ibutilide, Amiodarone

K channel blockers
KID SAD
K+
Ibitilide
Dofetilide
Sotalol
Amiodarone
Dronedarone
- blocks phase 2 and 3

**Amiodarone and Dofetilide are preferrede in AF patients with HF

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6
Q

Class IV Antiarrhythmics

A

nonDHP Ca+ channel blockers
EX: Verapamil, Diltiazem

more rate control! used to slow ventricular rate in AF

negative inotropic effect (decrease contraction force) ==== causing cardiac decompensation (avoid in HF)

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7
Q

Digoxin (Digox, Lanoxin)

A

Na-K-ATPase blocker to suppress AV conduction decreasing HR
enhances vagal tone and increases force of contraction (positive inotrope)

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8
Q

Adenosine

A

Activates adenosine recceptors to decrease AV node conduction for SVT

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9
Q

Nexterone

A

Amiodarone
K+ Channel blocker primarily with blockage of Ca and Na channels along with alpha and beta blockage

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10
Q

Sotalol

A

Beta blocker and K+ channel blocker

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11
Q

Dronedarone

A

K+ channel blocker primarily with blockage of Ca and Na channels along with alpha and beta blockage

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12
Q

Procainamide

A

Na+ channel blocker
Class1a
negative inotropic effect

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13
Q

Flecainamide

A

Na+ channel blocker
Class 1c
negative inotropic effect

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14
Q

Lidocaine

A

Na+ channel blocker
Class 1b
negative inotropic effect

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15
Q

Ibutilide

A

K+ channel blocker
KID SAD

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Arrhythmias (3 decks)

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