Mechanism of Action

Question 1

Mesalamine (Pentasa, Asacol HD)

Answer 1

exact MOA is unknown, may have anti-inflammatory effect in GI

Question 2

Infliximab (Remicade)

Answer 2

Anti-TNF agent that prevents induction of proinflammatory cytokines

**indicated for both CD and UC

Question 3

Methotrexate (Trexall)

Answer 3

Antimetabolite that has anti-folate mechanisms and anti-inflammatory effects

**Indicated for CD only

Question 4

Azathioprine

Answer 4

Immunosuppressive antimetabolite that blocks purine synthesis and also has anti-inflammatory effects

Question 5

Cyclosporine

Answer 5

Calcineurin Inhibitor that has immunosuppressive properties ONLY indicated for severe UC

Question 6

Ustekinumab (Stelara)

Answer 6

IL receptor antagonist

**indicated for anti-TNF intolerate mod-severe UC or CD patients

Question 7

Golimumab (Simponi)

Answer 7

Anti-TNF agent that blocks cytokines

**only indicated for UC

Question 8

Certolizumab (Cimzia)

Answer 8

Anti-TNF agent that blocks cytokines

**only indicated for CD