Mean Survival Times

Question 1

What is the most common oral neoplasm in dogs and what is its MST?

Answer 1

Malignant melanoma

MST less than 6 months

Question 2

What is the most common oral neoplasm in cats?

Answer 2

Oral squamous cell carcinoma

Question 3

Common liver tumours

Answer 3

Hepatocellular carcinoma 
Hepatoma 
Cholangiocarcinoma
Fibroma/fibrosacoma
Haemangiosarcoma/hemangioma

Question 4

MST for a dog with asymptomatic lymphoma without treatment?

Answer 4

4-6 weeks

Question 5

MST for a dog with lymphoma on prednisolone alone?

Answer 5

1-2 months

Question 6

MST with a high dose COP in canine lymphoma?

Answer 6

6-9 months

60-80% response rate

Question 7

MST for a discontinuous CHOP / CEOP?

Answer 7

10-12 months

90-95% response rate

Question 8

What is the MST for patients without metastatic disease after successful surgery and radiotherapy for a soft tissue sarcoma?

Answer 8

Less than 4y

Question 9

MST for splenic haemangiosarcoma if there is no metastasis after splenectomy?

Answer 9

4-6 months

Question 10

MST for splenic haemangiosarcoma after removal if there are metastasis?

Answer 10

4-6w

Question 11

Where are osteosarcomas usually found?

Answer 11

Near the knee

Away from the elbow

Question 12

How can you manage pain in osteosarcoma?

Answer 12

Amputation - pain free in a week
Opioids, NSAIDs, amantidine, paracetamol
Bisphosphonates (pamidronate)
Radiation therapy - 1-3m of pain relief

Question 13

What chemotherapy drug can be used to stabilise osteosarcoma metastasis?

Answer 13

Toceranib

Question 14

MST in a dog with osteosarcoma following amputation?

Answer 14

5-6 months

- 95% have mets by the time of diagnosis

Question 15

What is the MST of histiocytic sarcoma without treatment?

Answer 15

4-5 months

Question 16

MST for feline lymphoma without treatment?

Answer 16

4 weeks

Question 17

MST for feline lymphoma with chemotherapy?

Answer 17

5-6 months

Question 18

What chemotherapeutic agents are associated with anaphylaxis? LACC

Answer 18

L-asparaginase
Anthracyclines
Cytosine
Cisplatin

Question 19

What chemotherapy agents are associated with immediate vomiting?

Answer 19

Carboplatin

Antracyclines

Question 20

What chemo agents are associated with GI toxicity?

Answer 20

Most

Question 21

When does GI toxicity occur in chemo?

Answer 21

1-5 days post treatment

Question 22

When does myelosuppresion occur after chemo?

Answer 22

7-10 days post treatment

Question 23

What are the cut offs for chemotherapy in neutropaenic patients?

Answer 23

3x10^9 in dogs

2.5x10^9 in cats

Question 24

What is a side effect of doxorubicin and epirubicin?

Answer 24

Dilated cardiomyopathy

Question 25

What is a common side effect of cyclophosphamide?

Answer 25

Sterile haemorrhagic cystitis

Question 26

What is a common side effect of lomustine?

Answer 26

Hepatotoxicity

Question 27

What drugs must you never give to cats?

Answer 27

Cisplatin - fatal non-cardiogenic pulmonary oedema

5-FU - fatal CNS signs

Question 28

What chemo drugs are peri vascular irritants?

Answer 28

Vincristine, vinblastine - severe

Doxorubicin, epirubicin, actinomycin - catastrophic

Question 29

What drugs a used in metronomic chemotherapy and how should you monitor?

Answer 29

Low dose cyclophosphamide + priroxicam

• monitor neutropaenia with haematology
• monitor sterile haemorrhagic cystitis with urine dipsticks