McGowan DSA Week 1 Part 1 Flashcards
What are the three life-threatening non GI causes of abdominal pain?
MI (treat with chewable ASA)
Aortic Dissection (CXR with widened mediastinum)
PE (EKG with S1Q3T3)
What are the two types of esophageal perforation?
What is it called if it is a transmural rupture at the gastroesophageal junction?
Iatrogenic (trauma)
Spontaneous (vomiting/ETOH)
Boerhaave’s
How do patients present with Esophageal perforation?
What are the exam findings in Esophageal perforation?
Distressed
pleuritic/retrosternal pain, pneumomediastinum
How do you diagnose esophageal perforation?
How do you treat esophageal perforation?
CXR or CT chest with contrast
stabilize, NPO, parenteral Abx, surgery, endoscopic stenting
Where is subQ emphysema auscultated/palpated?
What is Hamman’s sign?
precordial area or neck
Auscultated; crunching rasping sign synchronous with heartbeat in left lat. decubitous position
What is the etiology (cause and location) of PUD?
H. Pylori
often in duodenal bulb or stomach
What is the H/P for PUD?
gnawing, dull, aching hunger pains
atypical chest pain
intermittent
mild, localized epigastric tenderness to deep palpation hyperactive bowel sounds
How is PUD diagnosed?
EGD with biopsy (to exclude malignancy)
Detection of H. Pylori with fecal antigen test or urea breath test
When does a patient stop PPIs before fecal antigen/urea breath test?
14 days prior to test
What is the treatment for PUD?
acid supression
eradicate H. Pylori
Stop smoking
endoscopic intervention
surgery
exclude malignancy
What are some complications of PUD?
ulcers along posterior wall can perforate into pancreas, liver, biliary tree, cause pancreatitis
What is the etiology of nutcracker esophagus?
hypertensive peristalsis (contractions too strong)
normal coordination, increased amplitude and duration
How is the LES affected in nutcracker esophagus?
relaxes normally, but has elevated pressure at baseline
What are the symptoms of nutcracker esophagus and diffuse esophageal spasm?
dysphagia to solids and liquids
atypical chest pain
What is the quality of the dysphagia in nutcracker esophagus and diffuse esophageal spasm?
intermittent, not progressive
How is the diagnosis of nutcracker esophagus made?
Manometry
How is the diagnosis of diffuse esophageal spasm made?
barium sallow and manometry
What is the LES function in diffuse esophageal spasm?
LES function is normal
What is the etiology of diffuse esophageal spasm?
abnormal coordination of peristalsis
barium swallow reveals corkscrew esophagus or rosary bead esophagus
What is the etiology of GERD?
ineffective motility
esophageal dysphagia with weak peristalsis
weak LES
What is the H/P for GERD?
heartburn/indigestion
“Waterbrash” (bad taste in mouth)
asthma, cough, hoarseness
How is the diagnosis of GERD made?
clinical diagnosis
order EGD or abd imaging if there are alarm features present, over age 60, or persistent sx despite tx.
What is the tx for GERD?
PPI>H2R blockers
lifestyle modification
surgery
H. Pylori eradication
What are the complications of GERD?
Laryngopharyngeal reflux
esophagitis
stricture
barret’s esophagus–>adenocarcinoma
What are alarm features if GERD is suspected?
What further evaluation is needed in this case?
unexplained weight loss
persistent cvomiting
melena
anemia
Endoscopy, ABD imaging, surgical eval.
What causes a sliding hiatal hernia?
herniation of stomach into mediastinum through esophageal hiatus due to increased intraabdominal pressure, pregnancy, heridtary
often causes GERD
What is a paraesophageal hernia?
What other complications can it cause?
herniation into the mediastinum including structures other than gastric cardia, commonly the colon
upside down stomach, volvulus, strangulation
What are risk factors for food impaction?
Schatzki ring
peptic (esophogeal) stricture
webs
esophagitis
achalasia
cancer
What are the symtoms of food impaction?
chest pain, pressure
dysphagia, odynophagia, sensation of choking
hypersalivation (frothing/drooling)
What is oropharyngeal dysphagia?
difficulty initiating swallowing
food sticks at supresternal notch
solids (cancer/web)
both solids and liquids (other causes)
What is the etiology of an esophageal web?
thin membrane in proximal or mid esophagus
congenital or acquired (EOE)
What is the H/P for an esophageal web?
esophageal dysplasia or oropharyngeal dysplasia (if prox.)
intermittent symptoms
not progressive
How do you diagnose an esophageal web?
Barium swallow
What is the treatment for esophageal web?
dilation and PPI longterm
What are the five features of Plummer-Vinson Syndrome?
Seen in mid-aged females
- chelitis
- glossitis
- esophageal webs
- koilonychia
- IDA
What is the etiology of Zenker diverticulum
false diverticula due to herniation through posterior cricopharyngeal m. and inferior pharyngeal constrictor m.
loss of elasticity of UES
occurs in Killian’s triangle
What are the H/P findings for Zenker’s Diverticulum
Oropharyngeal dyspahgia
halitosis, regurgitation, nocturnal choking, gurgling, protrusion
insidious/gradual onset
older males
How is the diagnosis of Zenker’s Diverticulum made?
video esophagography before EGD due to risk of perforation
What is the tx for Zenker’s Diverticulum?
surgery
Sjogren’s Syndrome (again, apparently we will talk about this in every system forever)
anti-ro/la abs
assx with B-cell non-hodgkin lymphoma
oropharyngeal dysphagia
What is esophageal dysphagia?
food sticks in mid to lower sternal area
both solids and liquids
Scleroderma (again, we will talk about this forever apparently)
Topoisomerase I ab
dysphagia
barret’s esophagus
primary biliary cirrhosis
GAVE syndrome
Esophagitis can be caused by the following:
Zollinger-Ellison syndrome
pill-induced esophagitis
resistance to PPI
medical noncompliance
What is the etiology of esophageal stricture?
structural issue
peptic esophageal stricture is common secondary to GERD or from EOE
What is the history for esophageal stricture?
gradual and progressive
solids and then both
heartburn lessens overtime, due to stricture barrier
How is the diagnosis of esophageal stricture made?
EGD (mandatory to differentiate peptic stricture from esophageal carcinoma)
What is the etiology of barrett esophagus?
specialized intestinal metaplastic columnar metaplasia replacing normal squamous mucosa of the distal esophagus
proximal displacement of the squamocolumnar junction
assx with GERD and truncal obesity
progresses to esophageal adenocarcinoma
obese WM >50y/o who smoke
What is the history of Barrett’s Esophagus?
mostly asymptomatic, may have hx of GERD
How is the diagnosis of Barrett’s esophagus made?
EGD on case-by-case basis with risk factors present
EGD with biopsy showing orange, tongue-like gastric epithelium extending into distal 1/3 of stomach
Biopsy: goblet and columnar cells
What is the management if Barrett’s Esophagus?
surveillance (high risk of CA in 3-5 years)
PPI to reduce cancer risk
What is the treatment for Barrett’s Esophagus?
PPI
Endoscopic ablation if high-grade dysplasia or intramucosal adenocarcinoma present
What is the etiology of squamous cell carcinoma of the esophagus?
most common type
M>F
What are the risk factors for Squamous cell carcinoma of the esophagus?
smoking, ETOH
achlasia, HPV, PVS, Tylosis
caustic chemical or thermal injury
What are the sx of Squamous cell carcinoma of the esophagus?
Dx?
Tx:
progressive dysphagia, weight loss, bleeding, cough
EGD with biopsy (likely mid-esophagus)
surgery
What is the etiology of adenocarcinoma of the esophagus?
Caucasians
M>F
distal 1/3 of esophagus
What are the risk factors of esophageal adenocarcinoma?
How is it diagnosed?
How is it treated?
GERD, barret metaplasia to dysplasia to cancer
EGD with biopsy (squamous to columnar)
Ablation
What is the etiology of esophageal ring (Schatzki)
structural issue
distal esophagus effected
assx with hiatal hernia
What is the history for Schatzki ring?
intermittent, not progressive
“Steakhouse” syndrome: food bolus impaction
How is the diagnosis made for Schatzki ring?
What is the treatment?
barium swallow
dilation, PPI
What is the etiology for Achalasia?
increases with age
motility disorder that is progressive, liquids and solids
failure of LES relaxation
loss of NO inhibitory neurons in myenteric plexus
What are the two types of Achalasia?
Primary: loss of ganglion cells within myenteric plexus
Secondary: Chaga’s dz from T. Cruzi protosoa
What is pseudoachalsia
tumors can invade gastroesophageal junction, resembling achalasia
What are PE findings for achalasia?
weight loss
2’: romana sign (periorbital edema)
Without treatment, achalasia can be described as what?
sigmoid esophagus
How is the diagnosis of achalasia made?
T. cruzi in smear (if 2’)
bird’s beak distal esophagus on barium swallow
Manometry confirms diagnosis
complete absence of normal persitalsis and incomplete lower esophageal sphincter relaxation with swallowing
What are risk factors for pill-induced esophagitis?
medications swallowed while supine or without water
what are risk factors for pill-induced esophagitis?
What are the symptoms?
Taking pill while lying down, not enough water
severe retrosternal chest pain, odynophagia, dysphagia
How is diagnosis of pill-induced esophagitis made?
based on history, possible ulceration
How to prevent pill-induced esophatitis?
take pills with 4-8oz of water and remain upright for 30min
What are the risk factors for infectious esophagitis?
immunosuppression
uncontrolled DM
corticosteroids
antibiotics
What are the common pathogens that occur with infectious esophagitis?
CMV
HSV
Candida
What will endoscopy show in CMV esophagitis?
one or more large, shallow ulcerations
What will endoscopy show in HSV esophagitis
multple, small, deep ulcerations
What will endoscopy show in candida esophagitis?
diffuse, large, linear white plaques adherent to mucosa
What is the history for EOE?
allergies/atopy
h/o food bolus impaction
How is the diagnosis made for EOE?
multiple circular esophageal rings creating a corrugated appearance
Bx with eosinophil predominant inflammation
What is the management of EOE?
dilation, PPI, glucocorticoid
risk of deep laceration or perforation with dilation, but very effective treatment
What are the complications of EOE?
food impaction
esophageal perforation
What are the symtoms of caustic esophagitis?
severe burning, chest pain, gagging, drooling
how is the diagnosis for caustic esophagitis made?
laryngoscopy
chest/abd radiographs to look for perforations
What are acute complications of caustic esophagitis?
perforation with pneumonitis
bleeding
fistulas
What are the long term complications for caustic esophagitis?
risk of esophageal squamous carcinoma is 2-3% warranting endoscopic surveillance 15-20 years after caustic ingestion
What is the treatment for caustic esophagitis
nasogastic lavage and oral antidotes SHOULD NOT be done
supportive care
laryngoscopy if resp. issues
EGD in 12-24 hours