GI Microflora in Health and Disease

Question 1

Which type of immune response (adaptive/innate) is induced in response to the increased gut permeability + bacterial components coming into direct contact with immune cells in IBD?

Answer 1

Adaptive immune response

Question 2

The combination of which 2 tests have a positive predictive value of 96% and a specificity of 97% for Chron’s disease?

Answer 2

• positive ASCA test (associated w/ Chron)
• negative pANCA test (associated w/ UC)

Question 3

Refined sugar may be a risk factor for which type of IBD?

Answer 3

Chron Disease, but not UC

Question 4

Fat intake has been linked to which IBD?

Answer 4

UC

Question 5

Fermentable fibers are fermented by gut bacteria producing which product important for gut health?

Answer 5

SCFA’s

Question 6

Which 2 drugs are risk factors for IBD?

Answer 6

1. NSAIDS
2. OC’s

Question 7

Which genes found on the IBD-1 locus have defects seen in cases of IBD?

Answer 7

CARD15/NOD2

Question 8

What is the function of CARD15 found on the IBD-1 locus?

Recognizes and triggers what?

Answer 8

• Intracellular pathogen recognition receptor (PPR)
• Recognizes muramyl dipeptide (MDP) structured molcules
• Triggers activation of NF-kB

Question 9

CARD15 is primarily expressed on what immune cells?

Answer 9

Monocytes/Macrophages

Question 10

Normal intestinal microflora may be important in the pathogenesis of__________

Answer 10

Celiac Disease

Question 11

Pathobionts are microorganisms associated with what conditions?

Answer 11

Chronic inflammatory

Question 12

Basal activation of which 2 immune cells provide cytokines that maintain integrity of the GI?

Answer 12

• Th17
• Th1