MC Questions

Question 1

You can safely prescribe Propranolol to treat high blood pressure in a patient who has bronchial asthma.

Answer 1

False

Question 2

Your patient developed a side effect of a drug you prescribed. You may lower the drug toxicity in this patient if…

Answer 2

You change the route of administration.

Question 3

All of the following are correct regarding Steroid receptors:

Answer 3

They bind to hydrophobic ligand
They have a masked DNA binding sites when they are not activated
They are intracellular receptors

Question 4

If there is an increase in the number of receptors, there is a need to —- the original dose of the drug to get the same result.

Answer 4

Increase

Question 5

——— is the dose at which 50% of experimental animals doe

Answer 5

Median lethal dose

Question 6

Competitive antagonists decreases the ability of an endogenous ligand to bind to its receptor to induce a biological response. In the presence of a competitive antagonist, what occurs to the EC50 of a ligand?

Answer 6

Increases

Question 7

A receptor with a constitutive activity means that it is more towards (Ra) form in absence of ligand

Answer 7

True

Question 8

All of following are correct

Answer 8

When a full agonist binds to a receptor, it stabilizes the active form of that receptor

Responses to low doses of a full agonist usually increase in direct proportion to the dose until all receptors are saturated

If the Kd is low, it indicates that the binding affinity of the drug to the receptor is high.

Question 9

The Kd of the agonist-receptor interaction determines what fraction of total receptors will be occupied at a given free concentration of an agonist

Answer 9

True

Question 10

As an antibody, one of the major mechanisms of trastuzumab is to attract immune cells to tumor sites that overexpress HER2

Answer 10

True