Equations

Question 1

P > 1; log P > 0

Answer 1

Lipid Soluble

Question 2

P < 1; log P < 0

Answer 2

Water Soluble

Question 3

Clearance

Answer 3

CL organ = Ke / C
Ke = rate of elimination
C = concentration

Question 4

Half-Life

Answer 4

t 1/2 = (0.7 x V) / CL

CL = V x Ke
Ke = 0.7 / t 1/2

Question 5

Extraction Ratio

Answer 5

ER = CL organ / Q

Average adult; 70kg : Q = 90 L/h

Question 6

Systemic Bioavailability

Answer 6

F = f x (1 - ER) (x 100%)

Question 7

Dosing Rate

Answer 7

Dosing Rate ss = CL x TC = CL x C
TC = target concentration

Dosing Rate oral =
Dosing Rate / F oral

Question 8

Maintenance Dose

Answer 8

MD = (Dosing Rate ss / F oral) x Dosing Interval

Question 9

Loading Dose

Answer 9

Loading Dose = (V x TC) / F

Question 10

Dosing Calculation

Answer 10

(Ordered Dose / Available Dose)
x number of Vehicles = Amount to give

Question 11

1 ng =

Answer 11

1 x 10^-6 mg

Question 12

Drug Effect
E =

Answer 12

(Emax x C) / (C + EC50)

Question 13

Fraction of Free Receptors
B =

Answer 13

(Bmax x C) / (C + Kd)

Question 14

B / Bmax =

Answer 14

C / (C + Kd)

Question 15

Volume of Distribution

Answer 15

V = Amount of drug in body /
Amount of drug in (blood + plasma + water)
V = A / C