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BPT Haematology > Mature Lymphoproliferative Diseases > Flashcards

Mature Lymphoproliferative Diseases Flashcards

1
Q

What differentiates lymphoma from leukaemia?

A

extent of bone marrow involvement

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2
Q

What are the clinical features of lymphoma?

A

lymphadenopathy in neck/axilla/groin
abdo pain
weight loss/fever/night sweats

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3
Q

What is Ann Arbor stage I?

A

a single group of nodes in a single radiation field

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4
Q

What is Ann Arbor stage II?

A

more than one group of nodes but all on the same side of the diaphragm

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5
Q

What is Ann Arbor stage III?

A

nodal disease across the diaphragm

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6
Q

What is Ann Arbor stage IV?

A

diffuse extra nodal involvement

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7
Q

What type of imaging should be used for routine staging of lymphoma?

A

PET-CT

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8
Q

What is the most common indolent/low grade lymphoma?

A

follicular lymphoma

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9
Q

What is the characteristic feature of follicular lymphoma?

A

Bcl-2 over expression

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10
Q

What is the median survival of follicular lymphoma?

A

20 years

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11
Q

What is the treatment for follicular lymphoma

A

anti CD20 therapy (rituximab or obintuzumab) and CVP or bendamustine or CHOP

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12
Q

Why should obinutuzumab and bendamustine combination be avoided in patients over 70?

A

high risk of infectious toxicities that can be fatal

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13
Q

What is the treatment for gastric MALT?

A

helicobacter eradication therapy

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14
Q

How is mantle cell lymphoma differentiated from CLL?

A

CD23 negative

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15
Q

What is the treatment of mantle cell lymphoma in young people?

A

R-DHAP x 4 + ASCT

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16
Q

What is the treatment of mantle cell lymphoma in older people?

A

R-bendamustine x 6

17
Q

What is the genetic abnormality in most patient’s with waldenstrom’s macroglublinaemia?

A

a single amino acid change in the MYD88 gene (L265P)

18
Q

What mutation causes hairy cell leukaemia?

A

BRAF V600E

19
Q

What are the main side effects of CHOP?

A 
mid cycle cytopaenias
hair loss
nausea/vomiting
peripheral neuropathy
cardiac toxicity
steroid side effects
20
Q

What are the elements of CHOP?

A

cyclophosphamide, doxorubicin, vincristine, prednisolone

21
Q

What are the two different chemotherapy options for Hodgkin lymphoma?

A

ABVD or escalated BEACOPP

BPT Haematology (10 decks)

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