Maternal History And Risk Flashcards
Maternal serum alpha fetoprotein (MSAFP)
16-18 weeks, neural tube defects if high, low can indicate T21
Glucose tolerance test
24-28 weeks, plus repeat H/H bc blood volume increases by 50%
RhoGham
Given at 28 weeks
Chorionic Villus Sampling
Chorionic tissue (inside layer of placenta) tests for fetal chromosomal anomalies, can test in 1st trimester. Can be transabdominal or transvaginal
Amniocentesis
Screen for chromosomal abnormalities, done in second trimester (have to wait for enough fluid). Uses fluorescence in situ hybridization (FISH)
Cordocentesis (Percutaneous Umbilical Blood Sampling - PUBS)
Takes blood from umbilical cord, guided by ultrasound. Test for blood disorders
Biophysical profile (BPP) variables
Fetal breathing movements, fetal movement, fetal tone, amniotic fluid volume, non-stress test
Fetal breathing movements (BPP)
Normal - one or more episodes lasting 30 seconds or more
Abnormal - absence of breathing movements or movements lasting less than 30 seconds
Fetal movement (BPP)
Normal- 3 or more body or limb movements
Abnormal - two or less
Fetal tone (BPP)
Normal - one or more episodes of active extension with return to flexion of limb or trunk, or opening and closing of hand
Abnormal - slow extension with return to partial flexion or absent movement
Amniotic fluid volume (BPP)
Normal - single vertical pocket >2cm
Abnormal - <2cm or no fluid
Non-stress test
Normal - reactive
BPP scoring
8-10 - normal
6 -10 - may be sleepy, watch and retest
4 or less - no reassuring, consider delivery
Preeclampsia
Hypertension with proteinuria (> 300mg/L)
HELLP
High blood pressure (hemolysis), elevated liver enzymes, low platelets
Superimposed PIH
Already had HTN, now worse due to pregnancy
CMV
Most common intrauterine infection, transmitted by exposure to infected blood or body fluids, most asymptomatic at birth.
Tx - gancyclovir
Oligohydramnios
AF <1 L at 36 weeks, < 800 ml at term
Potter sequence - renal agenesis, not urinating, no fluid, no lungs, can lead to hypoplastic lungs
Hydramnios (poly)
AF volume > 2L anytime
GI obstructions, tight nuchal cord (obstruction to swallowing), neuro defects, TE fistula
PROM
Premature rupture of membranes
PPROM
Preterm premature rupture of membranes (before 37 weeks)
Chorioamniotitis
Infection of placental membranes
Lectin/Sphigomyelin (L/S) ratio
Normal 2 or more
<2 indicates immature lungs, give steroids, try to stress baby, wait
>2 occurs when fetal lung surfactant is present in fluid (35 weeks)
Phosphatidylglycerol (PG)
If present in amniotic fluid, indicates lung maturity
More reliable than l/s ratio in diabetic moms