Material up to week 28 MCQ Flashcards
“Patch clamping” is commonly used to monitor the activity of which drug targets?
Ligand gated ion channels
A partial agonist is typically a drug that:
Can only produce a submaximal response
Botulinum toxin reduces transmission at the neuromuscular junction by which of the following mechanisms?
Inhibiting fusion of vesicles with nerve terminal membrane
Coupling of a G-protein alpha subunit to an agonist-occupied receptor initially leads to
Exchange of bound GDP with GTP
In G-protein coupled receptor signal transduction, protein kinase A is typically activated by
Cyclic AMP
Myasthenia gravis results from:
Reduced population of nicotinic acetylcholine receptors on postsynaptic cell
Neostigmine is an example of which type of drug?
Anticholinesterase
The principal neurotransmitter in the parasympathetic nervous system is:
Acetylcholine
The principal neurotransmitter in the somatic nervous system is:
Acetylcholine
The principal neurotransmitter in the sympathetic nervous system is:
Noradrenaline
What type of protein is the glucocorticoid receptor?
Steroid hormone receptor
What type of protein is the muscarinic acetylcholine receptor?
G protein-coupled receptor
What type of protein is the nicotinic acetylcholine receptor?
Ligand-gated ion channel
Where in a cell would you find the estrogen receptor?
Nucleus
Which of these terms is defined by the following? “The ability of a drug-receptor complex to elicit a biological response”.
Efficacy
Which of these terms is defined by the following? “The ability of a drug to bind to a receptor”.
Affinity
Which of these terms is defined by the following? “The ability of a drug to bind to one receptor and not another”.
Specificity
Which type of molecular interaction does an irreversible antagonist have with its receptor that a reversible antagonist does not?
Covalent bonds
