Mast Cell Activation

Question 1

Mast cell activation

Answer 1

a cascade of events that can occur with mold, Lyme, and other environmental triggers

Question 2

Mast cells are directly joined to nerve cells and trigger the release of biochemicals

Answer 2

True

Question 3

What immune response is coordinated by mast cells?

Answer 3

the response to toxins and infectious agents

Question 4

What do mast cells release to direct a proper immune response?

Answer 4

Granules, histamine

Question 5

Are mast cells problematic?

Answer 5

Only when overstimulated are mast cells destructive. This can happen with overloads of toxins mixed with genetics and biochemistry and result in over-stimulation to otherwise harmless stimuli such as light, touch, smells, foods.

Question 6

Does the contemporary medical model focus on short or long-term treatments?

Answer 6

Short-termed acute treatments. This can lead to incomplete healing.

Question 7

What is Naviaux’s fundamental premise for chronic disease management models?

Answer 7

They should reflect the conditions that give rise to the illness in the first place, not just managing the current state.

Question 8

Research supports the role of inflammation in psychiatric illness with links to what?

Answer 8

environmental toxin/toxicant exposures

Question 9

What drives a systems biology approach?

Answer 9

The interrelation of mental, physical, and environmental health

Question 10

What occurs in the CDR stages 1,2, and 3?

Answer 10

The CDR is a healing cycle where key metabolites signal the next stage of healing in cells. Interruptions in the cell-to-cell communication can lead to chronic disease

Question 11

From “Toxic”: Mast cell activation is often triggered by Lyme disease and mold exposure. Once activated, mast cells release_____, leading to a wide range of physiologic symptoms.

Answer 11

Histamine

Question 12

From Rapaport/Reynolds slides. Environmental exposures trigger a range of psychological and physiological responses including emotions, memories, immunity, microbiome changes, altered organ function and more.

Answer 12

True

Question 13

From Naviaux paper. CDR1 supports:

Answer 13

1. Excess inflammation and metabolic dam
2. Detection and removal of toxins
3. Activation of innate immunity
4. Adverse outcomes when triggered by bacteria, viruses, fungi, or chemical hazards
5. Medication delivery across lipid layers

Question 14

Viruses and bacteria are not able to cross the blood brain barrier (BBB)

Answer 14

False

Question 15

Rapid onset of mania or severe depression in patients in their 50s or 60s may be an indication of:

Answer 15

Mold exposure