Mass Transport (Chapter 7) Flashcards
Describe haemoglobin
A protein with 4 polypeptides, each associated with a haem group and each being able to carry an oxygen molecule.
Describe the role of haemoglobin and how it carries oxygen
1) Haemoglobin has a high affinity for oxygen - forms oxyhemoglobin in red blood cells.
2) Loading happens in lungs at a high partial pressure of oxygen.
3) Unloads/dissociates to respiring tissue at a low partial pressure of oxygen.
4) Unloading linked to higher carbon dioxide concentration.
Why does carbon dioxide cause a disassociation of oxygen?
(More respiration) more CO2 lowers the pH which reduces the affinity for oxygen by changing shape of haemoglobin so shifts curve to the right.
Why is the dissociation curve an s-shape?
1) Oxygen binds (to Hb causing a change in shape).
2) (Shape change of Hb) allows more O2 to bind easily/greater saturation with O2.
What is shown when a dissociation curve is shifted to the right?
1) Haemoglobin has a lower affinity for oxygen.
2) Dissociates to respiring tissue more readily at higher partial pressure of oxygen.
(3) Link to animal e.g. more oxygen for more respiration to generate heat.
What is shown when a dissociation curve is shifted to the left?
1) Haemoglobin has a higher affinity for oxygen.
2) Haemoglobin saturated and dissociates at lower partial pressure of oxygen.
(3) Link to animal
Describe the structure of the heart
Has 4 chamber - 2 atria and 2 ventricles and 4 vessels
How is pressure maintained in the heart?
Blood goes back to heart after lungs
What is the purpose of valves?
Stops blood from flowing backwards.
What are coronary arteries?
Arteries around the outside of the heart to provide oxygen to the heart muscle fibres.
Define myogenic
Beats by itself
Where does the aorta transport blood to and from?
Heart to body (oxygenated)
Where does the pulmonary artery transport blood to and from?
Heart to lungs (de-oxygenated)
Where does the pulmonary vein transport blood to and from?
Lungs to heart (oxygenated)
Where does the vena cava transport blood to and from?
Body to heart (de-oxygenated)
Describe the cardiac cycle
1) Diastole - relaxation. Blood in atria forces atria-ventricular valves to open. Semi-lunar valves close as pressure is lower in ventricles that arteries.
2) Atrial Systole - SAN transmits impulses to atria. Atria muscles contract and blood forced into ventricles.
3) Ventricular Systole - Wave of electrical activity passes from Atrioventricular Node (AVN) to atrial muscle.
4) Passes impulse to Bundle of His then to smaller muscle fibres at the bottom of ventricles.
5) Ventricles contract from bottom (apex of heart) upwards and blood is forced out through aorta.
What is the role of the SAN?
- Sends out electrical impulses
* Initiates the heartbeat/acts as a pacemaker/stimulates atria to contract
Why is there a short delay between electrical wave entering the AVN and leaving?
It allows the atria to empty and the ventricles to fill before the ventricles contract. This happens as there is a layer of non-conductive tissue between the atria and the ventricles.
Why is pressure higher in ventricles than atria?
Has more muscle so contractions are stronger.
What are arteries and their properties?
Vessels which carry blood away from the heart.
Thickest elastic, quite thick muscle layer, thin endothelium, no valves.