Mass Spectrometry

Question 1

How does alcohols undergo fragmentation

Answer 1

1. Alpha cleavage
2. Dehydration

Question 2

How does amines undergo fragmentation

Answer 2

1. Alpha Cleavage

Question 3

How does Carbonyl Compound undergo fragmentation

Answer 3

1. McLafferty Rearrangement

Question 4

Describe alpha cleavage

Answer 4

1. Beta Carbon is cleaved
2. Molecular Ion can resonance

Question 5

Describe McLafferty Rearrangement

Answer 5

1. Gamma Hydrogen forms a radical bond with carbonyl oxygen
2. Radical between Gamma Carbon and Gamma Hydrogen moves between Beta Carbon and Gamma Carbon
3. The Radicals Between Alpha Carbon and Beta Carbon are split. One goes between Beta Carbon and Gamma Carbon and One goes on Alpha Carbon

Question 6

Rule of Nitrogen mass spectrometry

Answer 6

The molecular ion peak is an odd number any time there is an odd number of nitrogen atoms in a molecule

Question 7

Rule of Halide mass spectrometry

Answer 7

Cl- 3:1
Br- 1:1