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neuropharmacology test 3 > maryam's flash card > Flashcards

maryam's flash card

1
Q

non-selective antagonist for 5-HT2 receptor

A

mesulergine and dibenzyline

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2
Q

Maryam’s Flash card

selective antagonist for 5-HT2c

A

Ritanserin

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3
Q

Maryam’s Flash card

selective agonist for 5-HT2a

A

DMT, DOM

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4
Q

Maryam’s Flash card

selective antagonist for 5-HT2b

A

metergoline

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5
Q

Maryam’s Flash card

selective antagonist for 5-HT2a

A

ketanserin

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6
Q

Maryam’s Flash card

selective agonist for 5-HT2c

A

Agomelatine

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7
Q

Maryam’s Flash card

partial agonists for 5-HT2a

A

LSD-25 psilocybine/psilocin, pyschedetic-phenylethylamine

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8
Q

Maryam’s Flash card

migrane therapy (5-HT1b, 5-HT1d agonist)

A

Ergotamine, zolmitriptan, naratriptan, rizatriptan, sumatriptan

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9
Q

Maryam’s Flash card

G-protein for 5-HT1 receptors

A

Gi

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10
Q

Maryam’s Flash card

antagonist for all 5-HT1 receptors

A

pindolol

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11
Q

Maryam’s Flash card

selective antagonist for 5-HT1b

A

Isamoltane

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12
Q

Maryam’s Flash card

selective antagonist for 5-HT1a

A

spiperone

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13
Q

Maryam’s Flash card

selective agonist for 5-HT1b

A

Ergotamine, Sumatriptan

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14
Q

Maryam’s Flash card

selective agonist for 5-HT1a

A

buspirone

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15
Q

Maryam’s Flash card

ubiquitous agonist for all 5-HT receptor

A

serotonin, quipazine

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16
Q

Maryam’s Flash card

5-HT1d

A

autoreceptors, human neuronal

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17
Q

Maryam’s Flash card

5-HT1b

A

autoreceptors, rodent neuronal

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18
Q

Maryam’s Flash card

fenfluramine

A

blocks both vesicular SERT and cell membrane SERT

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19
Q

Maryam’s Flash card

non-selective antagonist for all B receptors

A

propranolol

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20
Q

Maryam’s Flash card

selective antagonist foe B2 receptors

A

butoxamine

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21
Q

Maryam’s Flash card

selective agonist for B2 receptor

A

albuterol, salmeterol

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22
Q

Maryam’s Flash card

selective antagonist for B1 receptor

A

atenolol

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23
Q

Maryam’s Flash card

selective agonist for B1

A

xamoterol

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24
Q

Maryam’s Flash card

non-selective agonist of B receptors

A

NE, EPI, isoproterenol, ephedrine , pseudoephdrine, clenbuterol

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25
Q

Maryam’s Flash card

non-selective antagonist for alpha-2

A

Yohimbine

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26
Q

Maryam’s Flash card

suicide antagonist for alpha-1

A

Phenoxybenzamine

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27
Q

Maryam’s Flash card

partial agonists for alpha-2A

A

LSD-25

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28
Q

Maryam’s Flash card

non-selective agonist for alpha-2 receptor

A

NE, EPI, clonidine

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29
Q

Maryam’s Flash card

alpha-2B function

A

Vasoconstriction

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30
Q

Maryam’s Flash card

beta-Gamma subunit

A

inhibits VDCCs and activate CDKCs

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31
Q

Maryam’s Flash card

alpha-2A function

A

autoreceptors

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32
Q

Maryam’s Flash card

non-selective antagonist for all alpha-1 types

A

coryanthine

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33
Q

Maryam’s Flash card

selective agonists for alpha-1A receptor

A

TETRAHYDRAZOLINE

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34
Q

Maryam’s Flash card

non-selective antagonist for alpha receptors

A

phentolamine, prazosin

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35
Q

Maryam’s Flash card

non-selective agonist for alpha-1 receptors

A

DA, NE, EPI, phenylephrine, ephedrine, pseudoephrine

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36
Q

Maryam’s Flash card

MAOa and MAOb inhibitors

A

Iproniazid

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37
Q

Maryam’s Flash card

MAOb inhibitors

A

deprenyl

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38
Q

Maryam’s Flash card

MAOa inhibitor

A

befloxatone (reversible), harmaline (irreversable)

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39
Q

Maryam’s Flash card

COMT-I inhibitor

40
Q

Maryam’s Flash card

NET reuptake inhibitor

A

atomoxetine, reboxetine, imipramine, amitriptyline

41
Q

Maryam’s Flash card

NET and SERT reuptake inhibitor

A

Venlafaxine, duloxetine

42
Q

Maryam’s Flash card

DAT, NET and SERT reuptake inhibitor

A

indafraline, cocaine

43
Q

Maryam’s Flash card

DAT and NET reuptake inhibitor

A

bupropion, nomifensine

44
Q

Maryam’s Flash card

mAch receptor agonist for M1 only

A

pilocarpine

45
Q

Maryam’s Flash card

mAch receptor agonist for all five types of receptors

A

acethylcholine, carbachol, muscarine, oxotremorine

46
Q

Maryam’s Flash card

brucine

A

enhance muscarinic agonist binding to Ach binding site

47
Q

Maryam’s Flash card

mAch receptor antagonist for all five types of receptors

A

atropine, scopolamine, cyclopentolate

48
Q

Maryam’s Flash card

antagonist for just M4

A

tropicamide

49
Q

Maryam’s Flash card

antagonists for M3

A

Aclidinium

50
Q

Maryam’s Flash card

mAch receptor antagonist for inhibitory receptors (M2, M4)

51
Q

Maryam’s Flash card

mAch receptor antagonist for M2 only

52
Q

Maryam’s Flash card

mAch receptor antagonist for M1 only

A

pirenzepine

53
Q

3 drugs interfere with the binding of Mg to the ATPase proton pump site

A

guanethedine (antihypertensive) guanadrel (antihypertensive) bretylium (blocks arrhythmias) they do not cross BBB

54
Q

what is reuptake inhibitor for Dopamine and NE?

A

Nomifensin, Bupropion

55
Q

NE reuptake inhibitors?

A

Atamoxetine (strattera) (are not tricyclic) (called atypicall drug) OCD/ANX/DEP
Reboxetine (norebox) (are not tricyclic) (called atypicall drug) OCD/ANX/DEP

Imipramine (deprenil) Tricyclic antiDEP
Amitriptyline (Elavil) Tricyclic antiDEP

56
Q

MAOa specific reversible blocker?

A

Befloxatone

57
Q

MAOa specific irrevesible blocker?

58
Q

MAOa or b non specific irrevesable blocker?

A

Iproniazid

59
Q

MAOb sepcific irrevesable blocker?

A

Iproniazid

60
Q

what is the degratory enzyme for DA, HA?

61
Q

what is the degratory enzyme for EN, 5-HT?

62
Q

Alpha 1 non-selective antagonist ?

A

Phentolamine
Prazosin
Coryanthine

63
Q

suicide antagonist for alpha1?

A

Phenoxybenzamine

64
Q

selectve agonist for Alpha1a receptors?

A

Tetrahydrazoline (• Eye drops – constricts blood flows in the eyes and increase blood flow) cause Dry mouth

65
Q

non-selective agonist for alpha1 receptors?

A

DA
NE
EPI
Phenylephrine
Ephedrine
Pseudoephedrine

66
Q

Phenylethylamine hallucinogen relatives of NE?

A
  • LSD-25 (partial agonist)
  • NE has some hallucinogenic properties
  • Yohimbine as hallucinogenic properties
  • Mescaline - partial agonists for alpha2
  • Elimicin – comes from nutmeg
  • Ephedrine
  • Cathine
67
Q

non-selectie agonist for beta 1,2,3 receptor?

A

NE
EPI
Isoproterenol
Ephedrine
Clenbuterol

68
Q

selective agonist for beta1 receptors?

69
Q

selective agonist for beta2 receptors?

A

albuterol

salmeterol

70
Q

selective antagonist for beta 2 receptor?

A

Butoxamine

71
Q

selective anagonist for beta 1 receptors?

72
Q

non-selective antagonist for beta receptors?

A

propranolol

73
Q

what is the G-protein for beta receptors?

74
Q

what are the Vesicular Transport inhibitor?

A

reserpine, tetrahydrobenazine

75
Q

what other ion are requiered for synaptic dopamin Transporter DAT?

how is it blocked?

76
Q

what are the Dopamin specific reuptake inhibitor?

A

amineptine

methylphenidate

amphetamine

77
Q

what are the 2 NET and DAT reuptake inhibitor?

A

nomifensine,

bupropion

78
Q

Dopamin affect what kind of DA receptor?

A

affect all dopamin form D1 to D5 but affect D5 more

79
Q

Apomorphine affect what kind of DA receptor?

A

affect D1 to D5

80
Q

Bromocriptine affect what kind of DA receptor?

A

D2, D3, D4

81
Q

pramipexole affect what kind of DA receptor?

A

affect 2 and 3 but has higher affinity for 3

82
Q

Ropinirole affect what kind of DA receptor?

A

affect D2 and D3 but affect D3 more

83
Q

Spiperone antagonist affect what kind DAR?

A

affect D1 to D5 but affect D1 and D2 more

84
Q

Amisulpride antagonist affect what kind of DAR?

A

affect D2 and D3 but affect D2 more

85
Q

Chlorpromazine antagonist affect what kind DAR?

(neuroleptic)

A

affect D2,D3,D4

86
Q

Trifluoperazine antagonist affect what kind of DAR?

A

affect D2,3,4 but more D2

87
Q

Haloperidol antagonist affect what kind of DAR?

A

affect D2,3,4 but higher affinity for D2

88
Q

Risperidone antagonist affect what kind of DAR?

A

affect D2,3,4 but higheraffinity for D2

89
Q

Pimozide antagonist affect what kind of DAR?

A

affect D2,3,4 but affect D2 more

90
Q

irriversable anti cholinestrase drug?

91
Q

long lasting anti cholinestrase?

A

DDT, Diazinon, Malathion

92
Q

Vesamicol

A
  • Drug that is often used clinically
  • Interferes with vesicular transporter for ACh
  • Binds to same site as ACh so it cannot be transported
  • Can cross BBB and get inside cell (very lipophilic drug)
93
Q

inhibitory Ach receptor?

A

M2, M4 they act through Gi

94
Q

excitatory Ach receptors?

A

M1, M3, M5 they act through Gq

95
Q

amanita muscaria

A

Muscimol [GABAA] + Ibotenic acid [mGluR1,5] + muscarine

96
Q

Differential expression of mAChRs?

A
  • M1 expressed almost everywhere in nervous system
  • M3 are typically prominent in forebrain (all types of cortical structures)
  • M2 not as widely expressed – midbrain and brain stem
  • M4 are pretty common – basal ganglia and cortical areas

neuropharmacology test 3 (4 decks)

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