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neuropharmacology test 3 > Ach > Flashcards

Ach Flashcards

0
Q

Name the ligand affects all the muscirinic R?

A

Ach
Carbacol
Muscarine
Oxteromorine

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1
Q

What ligand is Ach modulator for binding?

A

Brucine

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2
Q

What is the specific ligand agonist for Ach M1 r?

A

Pilocarpine

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3
Q

What ligand is useful in lab and won’t get affected by AchE?

A

Carbacol

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4
Q

Name the mACHR antagonist non specific one?

A

Atropine
Scopolamine
Cyclopenyolate

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5
Q

Name specific antagonist for M1?

A

Pirenzepine

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6
Q

Name specific ligand for M2?

A

Gallamine

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7
Q

What mAchR him himbacine affect?

A

M2 and M4

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8
Q

Name specific antagonist for M3 mAchR ?

A

Aclidiniun

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9
Q

Name specific antagonist for M4 mAchR ?

A

Tropicamide

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10
Q

True or false: there are few specific drug for M5 R

A

False , there is no specific drug for M5

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11
Q

Name the region in the brain stem produce Ach?

A

DTN

PPN

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12
Q

Name 3 forbrain region involve in production of Ach and their projection?

A

MS: project to hippocampus
NDB: project to olfactory bulb
NBM: project to neocortex

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13
Q

DTN and PPN projects to

A

Rest of the brain

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14
Q

What is the third eye?

A

Habenula

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15
Q

Name the enzyme require for biosynthesis and degeradation of ACh?

A

ChAT and AchE

16
Q

Write the ACh biosynthesis and degradation

A

Acetyl coA + choline —– using ChAT ——ACh + CoA

ACh—-using AChE—— acetate + choline

17
Q

Name the anti cholinesterase that are organi phosphate that are irreversable:

A

Sarin

DDT

18
Q

Name the anticholinestrase that are long acting?

A

Diazinon

Malthion

19
Q

Name the AchE regenator:

A

Abidoxine

20
Q

Name anti cholinesterase that are clinically used:

A

Donepezil

Physostigmine

21
Q

Name the excitiory ACh R and their effector system:

A

M1, 3,5

Gq

22
Q

Name the inhibitory mAchR an their effector system?

A

M1,4

Gi

23
Q

Gi inhibit:

A

AC which inhibit the PKA through cAMP

24
Q

Gq activate the

A

PLC which activate the PkC through production of GAD and IP3

25
Q

M1 and 3 will block :

A

HVA through Gq

26
Q

Explain the smooth muscle contraction via m3 :

A

Slow depolarization via Gq beta gamma subunit

27
Q

Extremely slow IPSP through —— and ——- are inactivated by Gi mediated ———

A

M2 , GIRKs. Beta gamma

28
Q

Anti-AchE block—– block via —–useful for alzimer, which enhance the memory , ligand useful is —–

A

Slow AHP , m1,5 , dianapezil

neuropharmacology test 3 (4 decks)

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