Ach

Question 0

Name the ligand affects all the muscirinic R?

Answer 0

Ach
Carbacol
Muscarine
Oxteromorine

Question 1

What ligand is Ach modulator for binding?

Answer 1

Brucine

Question 2

What is the specific ligand agonist for Ach M1 r?

Answer 2

Pilocarpine

Question 3

What ligand is useful in lab and won’t get affected by AchE?

Answer 3

Carbacol

Question 4

Name the mACHR antagonist non specific one?

Answer 4

Atropine
Scopolamine
Cyclopenyolate

Question 5

Name specific antagonist for M1?

Answer 5

Pirenzepine

Question 6

Name specific ligand for M2?

Answer 6

Gallamine

Question 7

What mAchR him himbacine affect?

Answer 7

M2 and M4

Question 8

Name specific antagonist for M3 mAchR ?

Answer 8

Aclidiniun

Question 9

Name specific antagonist for M4 mAchR ?

Answer 9

Tropicamide

Question 10

True or false: there are few specific drug for M5 R

Answer 10

False , there is no specific drug for M5

Question 11

Name the region in the brain stem produce Ach?

Answer 11

DTN

PPN

Question 12

Name 3 forbrain region involve in production of Ach and their projection?

Answer 12

MS: project to hippocampus
NDB: project to olfactory bulb
NBM: project to neocortex

Question 13

DTN and PPN projects to

Answer 13

Rest of the brain

Question 14

What is the third eye?

Answer 14

Habenula

Question 15

Name the enzyme require for biosynthesis and degeradation of ACh?

Answer 15

ChAT and AchE

Question 16

Write the ACh biosynthesis and degradation

Answer 16

Acetyl coA + choline —– using ChAT ——ACh + CoA

ACh—-using AChE—— acetate + choline

Question 17

Name the anti cholinesterase that are organi phosphate that are irreversable:

Answer 17

Sarin

DDT

Question 18

Name the anticholinestrase that are long acting?

Answer 18

Diazinon

Malthion

Question 19

Name the AchE regenator:

Answer 19

Abidoxine

Question 20

Name anti cholinesterase that are clinically used:

Answer 20

Donepezil

Physostigmine

Question 21

Name the excitiory ACh R and their effector system:

Answer 21

M1, 3,5

Gq

Question 22

Name the inhibitory mAchR an their effector system?

Answer 22

M1,4

Gi

Question 23

Gi inhibit:

Answer 23

AC which inhibit the PKA through cAMP

Question 24

Gq activate the

Answer 24

PLC which activate the PkC through production of GAD and IP3

Question 25

M1 and 3 will block :

Answer 25

HVA through Gq

Question 26

Explain the smooth muscle contraction via m3 :

Answer 26

Slow depolarization via Gq beta gamma subunit

Question 27

Extremely slow IPSP through —— and ——- are inactivated by Gi mediated ———

Answer 27

M2 , GIRKs. Beta gamma

Question 28

Anti-AchE block—– block via —–useful for alzimer, which enhance the memory , ligand useful is —–

Answer 28

Slow AHP , m1,5 , dianapezil