Markers of Inflammation

Question 1

Which antibody can be found in bodily secretions such as - tears, saliva, intestinal mucus, breast milk, prostatic fluid?

Answer 1

IgA

Question 2

Which antibody is found in low amounts in the serum generally?

Answer 2

IgE

Question 3

Which antibody is produced after IgM production, rise in concentration, fall then stabilize?

Answer 3

IgG

Question 4

If an antigen test is positive is the infecting organism present?

Answer 4

yes

Question 5

Are antigen tests positive before or after antibody tests?

Answer 5

before

ex. Nucleic Acid Amplification Tests (NAATs)

Question 6

What is the name of the test that is non-specific detector of inflammation?

Answer 6

Erythrocyte sedimentation rate (ESR)

Question 7

If the ESR (erythrocyte sedimentation rate) is >50mm/hr should you be concerned?

Answer 7

Yes >50mm/hr is very significantly elevated

Question 8

Infectious, inflammatory, neoplastic, & necrotic diseases increase protein (mainly fibrinogen) content in plasma. What will this cause in RBC settling rate?

Answer 8

with increased protein RBCs descend faster = increased ESR

Question 9

What is the name of the non-speciic lab test primarily used to detect bacterial infection and inflammatory disorders (eg. rheumatoid arthritis)?

Answer 9

C-reactive protein

Question 10

Where is C reactive protein produced?

Answer 10

liver

Question 11

Which is more sensitive and rapid to respond - ESR or CRP?

Answer 11

C-reactive protein (CRP)

Question 12

Which lab test is (loosely) used to detect acute inflammation?

Answer 12

CRP

Question 13

Which lab test is (loosely) used to detect chronic inflammation?

Answer 13

ESR

Question 14

What is h-CRP used for?

Answer 14

marker of risk or predictor of future cardiovascular events.