Markers for Cardiac Injury Flashcards
Acute Coronary Synd consists of what 3 possible conditions?
Unstable angina
STEMI
NSTEMI
Unstable Angina is?
Angina that presents as:
Occurs at rest OR New onset and severe (limits activity) OR Worse (> severe, prolonged, frequent)
Non-cardiac chest pain characterized as? (7)
Pleuritic: sharp, related to resp or cough
Primary/sole location in mid/low abdomen
Localized w/ one finger
Reproduced by movement or palpation
Constant lasting several days
Fleeting pain (few seconds
Radiation to leg or above jaw
Cardiac Serum Markers?
Cardiac enzymes that indicate myo necrosis:
CK-MB (creatine kinase)
Troponins
Criteria for MI?
Cardiac Markers + one of:
Ischemic sxs
New path Q waves
ST elevation or depression
Imaging of new loss of myo or new abn regional wall motion
Unstable Angina vs MI?
UA:
ischemic sxs w/o ↑ CK-MB or trop,
w or w/o isch ECG ∆s
Troponin is?
Injury range:
MI range?
regulatory proteins that control Ca2+-mediated response of actin/myosin
1 - 1.4
> 1.4
Troponin timeline?
↑ starts 3-4 hrs post
Peaks 10-24 hrs
CK-MB is?
CPK-enz released w/ any mm or brain injury
CK-MB from heart
CK-MB timeline?
↑ starts 3-6 hrs post
Peaks 18-24 hrs
Back to normal 36-48 hrs
CK-MB sensit/specificty?
> 95% when measured w/i 24-36 hrs of chest pain
STEMI tx?
MONA (morphine, O2, Nitrates, Asp)
Initiate reperfusion
Reperfusion therapy?
Primary percutaneous coronary intervention (angio)
or Fibrinolysis
Anticoag therapy purpose?
β-blocker therapy purpose?
prevent rethromb
prevent recurrent ischemia and v arrhy
Unstable Angina and NSTEMI tx?
MONA
Ø Fibrinolysis
Anticoag
β-blocker
———– Bottom Line ———
Anticoag
Cardiology
