MAP 2 Flashcards

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1
Q

Which of the following is NOT an integral membrane protein?

A. actin
B. occludins
C. carrier proteins for mediated transport
D. connexons
E. channels for ion diffusion across membranes

A

A. actin

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2
Q

A primary active transport process is one in which __________.

A. the plasma membrane folds inward to form a vesicle containing extracellular material
B. molecules pass directly through the phospholipid bilayer of the plasma membrane
C. molecules move through transport proteins that have been activated by ATP
D. an intracellular vesicle fuses with the plasma membrane and releases its contents to the extracellular fluid
E. molecules move across the plasma membrane without an input of energy

A

C. molecules move through transport proteins that have been activated by ATP

Primary active transporters, such as the sodium-potassium ATPase (or pump), are activated when ATP is hydrolyzed. This activation allows for the transport of solutes across the plasma membrane against concentration gradients.

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3
Q

Some transport processes use transport proteins in the plasma membrane, but do not require ATP. This type of transport is known as _____.

A. simple diffusion
B. facilitated diffusion
C. endocytosis
D. exocytosis
E. active transport
A

B. facilitated diffusion

Facilitated diffusion is a passive transport process during which molecules move down their concentration gradients through transport proteins.

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4
Q

The majority of water molecules moving across plasma membranes by osmosis do so via a process that is most similar to ____.

A. facilitated diffusion
B. active transport
C. a process that requires energy from the cell
D. simple diffusion
E. cotransport
A

A. facilitated diffusion

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5
Q

The sodium-potassium pump uses ATP to move sodium and potassium ions across the plasma membrane. This statement describes _____.

A. primary active transport
B. exocytosis
C. secondary active transport
D. facilitated diffusion
E. simple diffusion
A

A. primary active transport

The sodium-potassium pump is activated by ATP. This activation allows the pump to transport sodium and potassium ions against their gradients.

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6
Q

A vesicle fuses with the plasma membrane and releases its contents to the extracellular fluid. This statement describes _____.

A. simple diffusion
B. active transport
C. facilitated diffusion
D. endocytosis
E. exocytosis
A

E. exocytosis

The term exocytosis literally means “out of the cell.”

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7
Q

If the equilibrium potential for K+ is -94mV, the Vm of a cell is -70mV, and K+ is more concentrated inside the cell, which of the following statements is true?

A. The inside of the cell has enough negative charge to prevent the outward movement of K+ and there will be no net movement of K+ across the membrane.
B. The inside of the cell has more than enough negative charge to prevent the outward movement of K+, and K+ will be drawn into the cell.
C. The inside of the cell does not have enough negative charge to prevent the outward movement of K+, and K+ will leave the cell under these conditions.
D. Since the Vm potential is normal, this means that there is no net movement of ions across the membrane.

A

C. The inside of the cell does not have enough negative charge to prevent the outward movement of K+, and K+ will leave the cell under these conditions.

Since the equilibrium potential is -94mV, that means that there needs to be more negative charge inside the cell than -70mV to prevent the chemical driving force from pushing K+ out of the cell. In order to get K+ to move into the cell, the Vm would need to be even more negative than -94mV.
Since the equilibrium potential is -94mV, that means that there needs to be more negative charge inside the cell than -70mV to prevent the chemical driving force from pushing K+ out of the cell.

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8
Q

If a 300 mOsm cell (10 mOsm of which are from the membrane-permeable molecule urea) is placed into 300 mOsm solution containing no urea, what will happen to the cell?
If a 300 mOsm cell (10 mOsm of which are from the membrane permeable molecule urea) is placed into 300 mOsm solution containing no urea, what will happen to the cell?

A. shrink (shrivel)
B. increased turgor
C. swell
D. burst
E. no change
A

A. shrink (shrivel)

If a 300 mOsm cell, of which 10 mOsm are from the membrane permeable molecule urea is placed into 300 mOsm solution containing no urea, the urea moves out of the cell down its concentration gradient. As a result, some water also moves out of the cell, so the cell shrinks.

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9
Q

In active transport, the transporter has equal affinity for the molecule being transported on both sides of the membrane.

A

False

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10
Q

What is the meaning of carrier proteins and pumps becoming saturated?

A

These transporters have reached a maximal net flux, beyond which further increases in concentration no longer affect their rate.

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11
Q

Molecules with a relatively high lipid solubility are capable of crossing the membrane

A. directly through the lipid bilayer.
B. only through specific protein channels.
C. only with the addition of energy.
D. indirectly by moving across a carrier protein.
E. through specific lipid channels.

A

A. directly through the lipid bilayer.

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12
Q

Which of the following will NOT increase the net flux of an ion across a membrane?

A. elevated permeability of the membrane
B. reduced surface area
C. increased concentration gradient across the membrane
D. more channels for that ion in the membrane
E. enhanced surface area

A

B. reduced surface area

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13
Q

Oxygen diffuses from blood into cells down its concentration gradient. As cells become more active and oxidative phosphorylation increases in the cell, which of the following occurs?

A. The concentration gradient for oxygen and its rate of movement into the cell do not change.
B. The concentration gradient for oxygen decreases and oxygen movement into the cell decreases.
C. The concentration gradient for oxygen increases and oxygen movement into the cell increases.
D. The concentration gradient for oxygen decreases and oxygen movement into the cell increases.
E. The concentration gradient for oxygen increases and oxygen movement into the cell decreases.

A

C. The concentration gradient for oxygen increases and oxygen movement into the cell increases.

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14
Q

The unequal distribution of charge in solutions on either side of a membrane will lead to a ________ of charge across the membrane and a ________ of counter ions in a region close to the membrane.

A. collection : clustering
B. separation : restriction
C. separation : clustering
D. buildup : restriction
E. collection : restriction
A

C. separation : clustering

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15
Q

Which ion(s) would have a positive equilibrium potential? (Assume a resting membrane potential (Vm) of -70mV.)

A. both X+ and B- ions
B. A-, whose [ECF] is100 mM and [ICF] is 100 mM
C. X+, whose [ECF] is120 mM and [ICF] is 30 mM
D. B-, whose [ECF] is140 mM and [ICF] is30 mM
E. X+ , A- , and B- ions

A

C. X+, whose [ECF] is120 mM and [ICF] is 30 mM

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16
Q

Which of the following hormones has intracellular receptors?

A. insulin
B. epinephrine
C. cortisol

A

C. cortisol

Yes, cortisol is one of the lipid-soluble steroid hormones. Thyroid hormones are also lipid soluble.

17
Q

What is the mechanism of action of lipid-soluble hormones?

A. activation of genes, which increases protein synthesis in the cell
B. increasing protein kinases
C. phosphorylation of intracellular proteins

A

A. activation of genes, which increases protein synthesis in the cell

Yes, lipid-soluble hormones diffuse into the nucleus or they diffuse into the cytoplasm and then move into the nucleus, where they affect transcription and translation.

18
Q

After a lipid-soluble hormone is bound to its intracellular receptor, what does the hormone complex do?

A. activates a protein kinase
B. directly alters protein synthesis at the ribosome
C. acts as a transcription factor and binds to DNA, activating a gene
D. phosphorylates a protein

A

C. acts as a transcription factor and binds to DNA, activating a gene

Yes, then mRNA is synthesized.

19
Q

Which hormone’s receptor is always bound to DNA, even when the receptor is empty?

A. cortisol
B. insulin
C. thyroid hormone

A

C. thyroid hormone

Yes, thyroid hormones are lipid soluble and their receptors are bound to the response elements of the DNA.

20
Q

What keeps intracellular receptors from binding to DNA before a hormone binds to the receptor?

A. chaperone proteins (chaperonins)
B. transcription factors
C. Receptors can’t enter the nucleus until the hormone is bound to it.

A

A. chaperone proteins (chaperonins)

Yes, each receptor has two binding sites. The chaperone protein blocks the DNA binding site until a hormone binds at the hormone binding site.

21
Q

Hormones can be transported in blood in dissolved form or bound to _____

A. receptors
B. growth factors
C. carrier proteins
D. enzymes

A

C. carrier proteins

22
Q

In chemical communication between cells, a ________ cell secretes a chemical messenger that binds to ________ on the ________ cell.

A. target : receptors : secretory
B. secretory : connexons : gap
C. secretory : connexons : target
D. gap : connexons : secretory
E. secretory : receptors : target
A

E. secretory : receptors : target

23
Q

A college student had a very poor diet during her first semester away from home. She tried convincing her parents that her poor diet caused her to receive a failing grade in physiology due to the fact that her lack of nutrient intake caused her to run low on amino acid neurotransmitters–which, of course, hindered her ability to learn. Should her parents believe her?

A. No, they should not believe her.
B. Yes, they should believe her.

A

A. No, they should not believe her.

The amino acids used as neurotransmitters in the body are derived within the body itself, not from amino acids brought in through digestion of proteins.

24
Q

If a person had a disease in which carrier proteins were nonfunctional, what might happen?

A. The person’s blood could not transport hydrophobic hormones but would still be able to transport all hydrophilic hormones.
B. The blood could not transport any hormones at all.
C. All hormones would be preserved in the blood for much too long (their half-lives would be overly extended).
D. The person’s blood could not transport hydrophobic and some hydrophilic hormones.

A

D. The person’s blood could not transport hydrophobic and some hydrophilic hormones.

Carrier proteins are used not only for hydrophobic hormones but also for some nonlipid hormones.

25
Q

The steroid hormones cortisol and aldosterone are almost identical structurally. What do you predict would happen if a person had a supraphysiological level of cortisol?

A. Cortisol would bind only to its own receptors.
B. Cortisol would bind to the aldosterone receptor.
C. Cortisol would display nonspecific binding with G protein-coupled receptors.
D. Cortisol would show nonspecific binding with enzme-coupled receptors after saturation of its own receptors.

A

B. Cortisol would bind to the aldosterone receptor.

Due to the structural similarity, you would expect to see cortisol binding to aldosterone receptors as well as its own.

26
Q

When the alpha subunit of the G protein is activated, it can stimulate ion channels to do what?

A. open only
B. close only
C. degrade
D. alter the ion that travels through the channel
E. either open or close
A

E. either open or close