MAO inhibitors

Question 1

MAO A

Answer 1

• Degrades NE, 5HT, DA, tyramine

- found in GI & nerve endings

Question 2

MAO B

Answer 2

• Degrades phenylethylamine, DA, tyramine

- found in glial cells &platelets

Question 3

MAO A inhibitors

Answer 3

• Moclobemide (reversible)
• Clorgiline (irreversible)

–> used in depression

Question 4

MAO B inhibitors

Answer 4

-Selegiline (irreversible)

–> increased dopamine so used in Parkinson’s. It’s neuroprotective

Question 5

MAOi side effects

Answer 5

1. Cheese reaction if no tyramine free diet
2. too much serotonin if concomittant use of MAOi with SSRI or TCA
3. insomnia & excitation ( increased serotonin )
4. sexual disfunction

Question 6

MAOi indications

Answer 6

1. depression but not 1st choice

2. phobias (taken 2-3/ day because of short duration)

Question 7

Clorgiline side effect

Answer 7

• used in depression but not first choice because of the cheese effect (HTN crisis) if there is no lack of tyramine in the diet.

Question 8

Non selectibe MAOi

Answer 8

• Phenelzine (irreversible)
  -tranylcypromine
  -pargyline
  used in severe cases of depression

Question 9

MAO

Answer 9

-secondary agents
-esp for atypical depression
(those that don’t respond to classic treatment with reuptake inhibitors)