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Ama - Parkinson's disease > MAO-B inhibitors > Flashcards

MAO-B inhibitors Flashcards

1
Q

MoA

A

Inhibits monoamine oxidase B enzymes which breakdown monoamines e.g. dopamine

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2
Q

When are they used?

A

Used alone in PD with motor symptoms that do not affect QoL
OR as an adjunct to Levodopa

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3
Q

Examples

A

Selegeline
Rasagiline

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4
Q

Selegiline

A

Amphetamine is one of its metabolites
Driving offence (due to CNS stimulant effects)

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5
Q

Interactions - hypertensive crisis

A

Pseudoephedrine, phenylephrine, xylometazoline, oxymetazoline (OTC interactions: nasal decongestants)

Adrenaline, noradrenaline, methylphenidate, amphetamines, B2 agonists (drugs that increase BP: sympathomimetics)

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Ama - Parkinson's disease (5 decks)

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