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Ama - Parkinson's disease > COMT inhibitors > Flashcards

COMT inhibitors Flashcards

1
Q

MoA

A

Inhibits catechol-O-methyltransferase.
Prevents peripheral breakdown of levodopa = more levodopa reaches the brain

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2
Q

Catechol-O-methyltransferase

A

Enzyme that degrades catecholamines (dopamine, adrenaline + noradrenaline)

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3
Q

When are they used?

A

Adjunct to levodopa in “end of dose” motor fluctuations.

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4
Q

Examples

A

Entacapone - makes urine reddish/brown
Tolcapone - hepatotoxicity (report signs of liver toxicity)

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5
Q

Interactions - increased CV (sympathomimetic) effects

A

Adrenaline
Noradrenaline
MAOIs e.g. tranylcypromine

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Ama - Parkinson's disease (5 decks)

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