many-paws Flashcards

1
Q

changes in menses occur when

A

-3a (late reproductive stage)

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2
Q

inc in FSH when

A

-1 late menopausal stage

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3
Q

amenorrhea can last >60 days

A

-1 late menopause

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4
Q

perimenopause spans

A

-2 to +1
early menopausal transition to early menopause

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5
Q

decline in fecundity is a hallmark

A

-3a
late reproductive years

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6
Q

indications for HRT

A

moderate to severe VMS
prevention of osteoporosis
premature hypoestrogenic state (such as POI or post BSO)
GUSM

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6
Q

baseline labs for menopause

A

height/weight/BMI
abd circumference
breast exam
pelvic exam
papsmear
TV-UTZ
digital mammogram starting 40
TSH (q5 at 35 then q1 at 60)
FBS, lipid profile
Crea, BUN, UA
LFT
colonoscopy at 50 then q10
STI screen
immunization record
dexa q2 yrs after 65 unless with symptoms
vices

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7
Q

transdermal if

A

at risk for vte
hyper-TGL
obese with metabolic syndrome
diabetic and hypertensive
smokers
hyposexual/dec libido

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8
Q

vaccines required for elderly

A

HPV
influenza annual
shingles/zoster
pneumococcal PPSV23 annual
TDAP q10 yrs

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9
Q

low dose estrogen

A

0.3 - 0.45 CEE
E2V 0.5
Estrogel 0.5mg (1/3 of ruler ~0.5mg)
17B estradiol 0.5-1mg
transdermal 25-37.5 mcg

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10
Q

for GUSM (vaginal)
3 - vagifem, ovestin, estring
1- DHEAS
1 - oral

A

vagifem tab/estradiol hemihydrate 10mcg/tab 1 tab daily x 2 weeks then 1 tab 2x/week

ovestin cream (estriol) 0.5g cream = 0.5mg estriol
1 applicator for 1st 2-3 weeks max 4 weeks

ESTRING: silicone ring with 2 mg estradiol (7.5 μg/day for 90 days)

Prasterone 0.5% 6.5mg intravaginal gel

Ospemifene 60mg OD

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11
Q

transdermal example

A

estradiol hemihydrate gel
oestrogel 48mg/80g tube

transdermal estradiol patch
climara 75mcg/patch

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12
Q

moderate dose estrogen

A

0.625mg CEE
E2V 1mg
Estrogel 1 mg (2/3 of ruler ~1mg)
17B estradiol 1.5-2mg
transdermal E2 50mcg/day

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13
Q

high dose estrogen

A

1.25 CEE
E2V 2
Estrogel 1.5mg
17B estradiol 2mg
transdermal 75-100 mcg

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14
Q

low dose progesterone

A

Dydrogesterone 5mg
Micronized progesterone 100mg
MPA 5mg (if cont 2.5mg)
NETA 1.25mg (0.5-1mg if cont)
LNG-IUS 52mgc(20mcg daily)

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15
Q

high dose progesterone

A

Dydrogesterone 10mg
Micronized progesterone 200mg
MPA 5-10mg (if cont 2.5-5mg)
NETA 1.25mg-2.5 (1-2.5mg if cont)
LNG-IUS 52mg

16
Q

SERMs

A

Raloxifene 60mg (high risk for VTE)
Ospemifene 60mg
Bazedoxifene 20mg + CEE

*no effect for hip and wrist fractures but decreased vertebral fracture

17
Q

STEAR

A

selective tissue estrogenic activity regulator

tibolone 2.5 mg

18
Q

bisphosphonates prevention

A

Alendronate 35mg PO 1x/week
Zolendronic Acid 5mg IV

19
Q

bisphosphonates tx

A

Alendronate 70mg PO 1x/week
Zolendronic Acid 5mg IV

20
Q

bisphosphonates side effects

A

ulcer
gi upset
takes 10 years to clear out of system –> will manifest as pain
osteonecrosis of the jaw (slow bone turnover so osteomyelitis with necrosis)

21
Q

MOA bisphosphonates

A

inhibits bone resorption
increase osteoclast apoptosis
reserve for older menses

22
Q

monoclonal antibody to rankL

A

denosumab

23
Q

Teriparitide 20mg SQ

A

PTH inc bone formation

tx for osteoporosis

24
Q

TSEC

A

tissue selective estrogen complex

bazedoxefine

25
Q

calcium and vit D

A

1000-1200IU ca
600 IU ca

26
Q

bone losing meds

A

glucocorticoids
hyperthyroid
SSRI
proton pump inhibiting drugs like omep (inc PTH, dec Ca absorption)
aromatase inhibitors
thiazolidinediones

27
Q

contraindications to HRT

A

breast CA (estrogen dependent cancers)
VTE
undiagnosed vaginal bleeding
active liver disease
CHD
Stroke
MI

28
Q

SSRI

A

Citalopram Celexa 20mg
Fluoxetine Prozac 20mg
Setraline Zoloft 50-100mg
Paroxetine Paxil 12.5-25mg

29
Q

SNRI

A

Venlaxafine Effexor 37.5/75/150mg
Desvenlaxafine Pristiq 100mg

30
Q

Non hormonal

A

Gabapentin 900mg
Pregabalin Lyrica 150mg