Mantle Cell

Question 1

What is mantle cell lymphoma?

Answer 1

Aggressive mature b cell non hodgkin lymphoma

Question 2

Who is affected?

Answer 2

Males are more affected (6:1) and on presentation there are multiple large nodes affected

Question 3

What is the median survival?

Answer 3

3-5 years has the worst of the b cell lymphomas it frequently relapses

Question 4

What is seen on the morphology?

Answer 4

LOw rate of somatic hypermutation of V gene in small pre-germinal centre b cells

Question 5

What is the immunophenotype?

Answer 5

Aberrant CD5,
CD19 CD20 CD22 delta chain, sIgM/D
CD10 , 23 negative

Question 6

What are the cytogenetics of mantle cell lymphoma?

Answer 6

50-75% are associated with t(11;14) and cyclin d1 overexpression - BCL 1 igH fusion gene leading to upregulated BCL1 and increased cycin D1 and cell proliferation
this same mutation is seen in large cell lymphoma, CLL and MM