Managing Canine and Feline Liver Disease Flashcards
List examples of supplements for hepatoprotection
S-adenosylmethionine (SAMe)
Silymarin
Ursodeoxycholic acid (UDA)
N-acetylcysteine (NAC)
What drug to give cat with Paracetamol (Acetaminophen) toxicity
N-acetylcysteine (NAC)
Antibiotics to avoid in liver disease
Avoid tetracycline, sulphonamides, erythromycin, use lower dosages of metronidazole
Treatment Copper Storage
D- Penicillamine - binds copper and excretes via kidneys
Dietary Management- Low copper diet, with added zinc
Oral Zinc
Leptospirosis Treatment
Doxycycline PO
Leptospirosis Diagnosis
antibody-based tests and polymerase chain reaction (PCR). Paired acute and convalescent microscopic agglutination test (MAT) are diagnostic for leptospirosis.
Ascites Treatment
Diuretics- Spironolactone/ Furosemide
Abdominocentesis
Hepatic Encephalopathy and what disease is associated with it
Hepatic Encephalopathy
Associated with portosystemic shunt, cirrhosis, acute fulminant hepatic failure
Most significant toxin associated with heaptic encephalopathy
Hyperammonaemia
Treatment of Hepatic Encephalopathy
Protein restriction
Antibiotics: Metronidazole (low dose 7.5 mg/kg BID)/ Amoxicillin and clavulanic acid
Lactulose
Fluid therapy
Gastroprotective medication
Treat seizures with Diazepam/Midazolam
Hepatic Lipidosis
Negative energy balance, usually caused by anorexia leads to enhanced mobilisation of fat stores to the live
Abnormal accumulation of lipids in the hepatocytes
Severe intrahepatic cholestasis, hepatic dysfunction
Biochemistry level of ALP and GGT IN hepatic lipidosis
↑ ↑ ALP, normal GGT
Hepatic Lipidosis- Treatment
Feeding tube- High quality diet, high protein, +/- taurine, B vitamins
Monitor glucose and electrolytes, especially K+ and PO₄³⁻
IVFT, Vitamin B12 and K, Antiemetics, antioxidants
