management of heart failure

Question 1

what drugs can be given to improve contractility?

Answer 1

1. cardiac glycosides-digoxin
   2.sympathomimetic amines-beta adrenergic agonist-
   dopamine, epi, norepi, dobutamine, isoproterenol, phosphodiesterase inhibitors

Question 2

what drugs can we give for preload reduction

Answer 2

decrease intravascular volume and venous dilation

• diuretics furosemide, bumetanide, thiazides
• ARBS-spironolactone, eplerenone
• vasopressin antagonist-conivaptan and tolvaptan
• vasodilators-organic nitrates

Question 3

What drugs can we give for afterload reduction?

Answer 3

decrease SVR, decrease RAAS/AT1 receptor activation

ace inhibitors-captopril

ARBS-losartan, irbesartan

B adrenoceptors Antagonist -propranolol

vasodilators-organic nitrates, hydralazine, and nitrate combination