Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pharm 2 Module 1.1-1.2 > Drugs-MOA and site only > Flashcards

Drugs-MOA and site only Flashcards

1
Q

Acetazolamide Diamox
MOA
renal site of action

A
  • Inhibition of renal carbonic anhydrase to decrease sodium and bicarb reabsorption
  • PCT
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

verapamil Covera-HS, Calan

A

Calcium channel blockers - vasodilators

non-dihydropyridines: Prefer open confirmation of L-type calcium channel (heart) and block it

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

labetalol Trandate

A

labetalol Trandate

B1/B2/a1 antagonist (7:1)

A1: decrease in SVR

B1: prevents reflex increase in heart rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

nifedipine Procardia, Adalat

A

nifedipine Procardia, Adalat

Calcium channel blockers - vasodilators

Dihydropyridines; prefer to bind to the inactivated state of L-type calcium channel and block it

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

captopril Capoten

A

ACE inhibitors: decrease angiotensin II levels and increase bradykinin levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

desmopressin/DDAVP

A
  • V2 selective agonist, : more potent antidiuretic as compared to vasopressin
  • Vasopressin Receptor Agonist
  • Collecting Duct
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Sodium thiosulfate

A

Treatment of cyanide toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

3% sodium nitrate

A

Treatment of cyanide toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

bosentan Tracleer

A

Endothelin (ET) receptor antagonist
Nonselective

Endothelin (Gq coupled) leads to contraction of smooth muscle; thereby relaxation is caused by antagonism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

losartan Cozaar

A

ARB

Angiotensin receptor blockers (ARB) at AT1 receptors

Vasodilation, renal vasodilation on efferent, block Na+ reabsorption, block SNS discharge, inhibit ADH release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

isoproterenol

A

Beta adrenergic agonist (synthetic agonist with relative selectivity for Beta1 > Beta2)

Beta1 - Positive inotrope, chronotrope, lusitrope.
Beta2 - peripheral vasodilation and hypotension. No activity on alpha

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

vasopressin /pitressin
MOA
renal site of action

A
  • Vasopressin Receptor Agonist
  • V1: Gq coupled on vascular smooth muscle, V1: vasoconstriction
  • V2: Gs coupled on vascular endothelium and collecting duct: phosphorylation of AQP2, V2: release of coagulation factors, water reabsorption, Conserve body fluid, prevent fluid loss, maintain perfusion
  • Collecting Duct
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

atenolol Tenormin
MOA

A

B1 selective antagonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

dopamine

A

Beta adrenergic agonist

Low dose: D1 vasodilation and increase in renal blood flow

Intermediate: B2 and B1: increase HR/contractility, decreased SVR

High: A1 peripheral vasoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

bumetanide/bumex
MOA
renal area of action

A

loop diuretic

Inhibition of Na+ reabsorption in thick ascending Loop of Henle by blocking NKCC2 (Na+/K+/Cl-) transporter

Thick ascending limb of LOH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

ambrisentan Letairis

A

Endothelin (ET) receptor antagonist
Selective

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

triamterene Dyrenium
moa
site of action

A

potassium sparing diuretic
collecting duct

Liddle’s syndrome (super ENaC Na channel)

Block ENacC Na channel.

Contradications - ACE, ARBs, renal insufficiency with hyperkalemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

hydralazine Apresoline

A

Decrease vascular smooth muscle tone (Mechanism unclear)

Direct relaxation of arteriolar smooth muscle (mechanism unclear)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

lisinopril Prinivil, Zestril

A

ACE inhibitors: decrease angiotensin II levels and increase bradykinin(vasodilation) levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

epinephrine

A

Beta adrenergic agonist

Low dose - Beta1 - positive inotrope, lusitrope, chronotrope, and dromotrope, also vasodilation in SKM;
High dose - alpha1 - generalized peripheral vasoconstriction increasing afterload

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

phenoxybenzamine Dibenzyline

A

phenoxybenzamine Dibenzyline

alpha1, alpha 2 antagonist

A1 and A2 adrenergic receptor antagonist- irreversibleblocks resulting in longer half life and very long duration of action (central dogma)

22
Q

hydrochlorothiazide HCTZ
MOA
site of action in kidney

A
  • hydrochlorothiazide HCTZ
  • Block Na+/2Cl- cotransporter in the DCT, inhibition of NaCl reabsorption in the DCT, increase absorption of Ca2+
  • Vasodilatory effect
  • Thiazides
  • DCT
23
Q

amlodipine Norvasc

A

Calcium channel blockers - vasodilators

Dihydropyridines; prefer to bind to the inactivated state of L-type calcium channel and block it

24
Q

phentolamine OraVerse, Regitine

A

alpha1, alpha 2 antagonist

25
metoprolol Lopressor, Toprol MOA
B1 selective antagonists Antagonism of **B1** in the heart, renal juxtaglomerular cells
26
mannitol/osmitrol MOA renal site of action
* mannitol/osmitrol * PCT (primary), loop of Henle (secondary) * osmotic diuretic, Molecules that are filtered into the glomerulus and not reabsorbed, limits reabsorption of water
27
irbesartan Avapro, Aprovel
ARB Angiotensin receptor blockers **(ARB)** at AT1 receptors Vasodilation, renal vasodilation on efferent, block Na+ reabsorption, block SNS discharge, inhibit ADH release
28
dobutamine
Beta adrenergic agonist (synthetic sympathomimetic amine)
29
fenoldopam Corlopam
D1 dopamine receptor agonist Peripheral D1 dopamine receptor agonist Decrease SVR, increase renal blood flow
30
digoxin Digox, Lanoxin
Cardiac glycosides raise intracellular calcium by inhibiting Na/K ATPase pump on sarcolemma
31
Conivaptan/vaprisol MOA renal site of action
* Nonselective vasopressin antagonist V1 blockade: vasodilation * V2 blockade: water excretion from collecting duct * Collecting Duct
32
diltiazem Cardizem, Dilacor
Calcium channel blockers - vasodilators non-dihydropyridines: Prefer **open** confirmation of L-type calcium channel (heart) and block it
33
aliskiren Tekturna
Renin inhibitor Decreases SVR and Na+ absorption by kidney
34
Spironolactone Aldactone MOA site of action
* potassium sparing, * Spironolactone Aldactone * Aldosterone/mineralcorticoid receptor antagonist, **inhibit synthesis of ENaC Na+ channel** * Collecting duct
35
norepinephrine
Beta adrenergic agonist Low dose - Beta1 - positive inotrope, lusitrope, chronotrope, and dromotrope, alpha1 - vasoconstriction with increased afterload. Little effect on Beta2
36
milrinone Primacor
Phosphodiesterase (PDE)3 Inhibitor Positive inotrope (improves diastolic dysfunction), vasodilation. Blocks metabolism of cAMP (inotropic effects), cGMP (vasodilatory effects) Increased inotropy, increased lusitropy, decreased SVR, decreased preload (increased venous capacitance)
37
methylene blue MB
eNOS inhibitor Vasoconstriction
38
doxazosin Cardura
alpha1 antagonist
39
Hydroxocobalamin Vitamin B12
Treatment of cyanide toxicity
40
tolvaptan/samsca MOA renal site of action
* V2 selective, Vasopressin Receptor Antagonist V2 blockade: water excretion * Collecting Duct
41
terlipressin MOA renal site of action
* V1 selectivity and partial agonist * Vasopressin Receptor Agonist * Collecting Duct
42
minoxidil Loniten, Rogaine, Renewal
Potassium channel opener arterial dilation and renal venodilation Opening of ATP-modulated **K+ channels** resulting in hyperpolarization
43
furosemide/lasix MOA renal site of action
loop diuretic, Inhibition of Na+ reabsorption in thick ascending **Loop of Henle** by blocking NKCC2 (Na+/K+/Cl-) transporter Thick ascending limb of LOH
44
Digibind
Anti-digoxin antibodies
45
chlorothiazide/diuril MOA site of action
thiazides DCT Block **Na+/2Cl- cotransporter** in the **DCT**, inhibition of NaCl reabsorption in the **DCT**, increase absorption of Ca2+
46
amiloride Midamor MOA site of action
* amiloride Midamor * potassium sparing diuretic * collecting duct * Pharmacological **blockage of ENaC Na+ channel** (**not synthesis of the channel like Spironolactone**) Liddle's syndrome (super ENaC Na channel)
47
propranolol Inderal, Innopran MOA
Nonselective beta antagonist
48
terazosin Hytrin
alpha1 antagonist
49
prazosin Minipress
alpha1 antagonist Block **A1** adrenergic receptors, greater effect in arterioles resulting in vasodilation
50
eplerenone Inspra MOA site of action
* eplerenone Inspra * Aldosterone/mineralcorticoid receptor antagonist - potassium sparing * Collecting duct

Pharm 2 Module 1.1-1.2 (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions